4-(4-氟苯基)-1,2,3,6-四氢吡啶合成路线 （共 11 条）
反应条件
acetic acid; zinc in water
T=45°C;
参考文献
Perregaard; Moltzen; Meier; Sanchez
Journal of Medicinal Chemistry, 1995 , vol. 38, # 11 p. 1998 - 2008
反应条件
sodium hydroxide in water
参考文献
NEUROCHEM (INTERNATIONAL) LIMITED
Patent: WO2004/113275 A2, 2004 ;
Location in patent: Page 166 ;
反应条件
1: 1.) n-BuLi / 1.) n-hexane, diethyl ether, -50 deg C, 40 min, 2.) n-hexane, diethyl ether, from -50 deg C to -10 deg C
2: 96 percent / trifluoroacetic acid / 1.5 h / Heating
3: 93 percent / 1,1,1-trichloro-ethane / 3 h / Heating
4: 93 percent / Zn (powder), acetic acid / H2O / 45 °C
View Scheme
参考文献
Perregaard; Moltzen; Meier; Sanchez
Journal of Medicinal Chemistry, 1995 , vol. 38, # 11 p. 1998 - 2008
反应条件
1: 96 percent / trifluoroacetic acid / 1.5 h / Heating
2: 93 percent / 1,1,1-trichloro-ethane / 3 h / Heating
3: 93 percent / Zn (powder), acetic acid / H2O / 45 °C
View Scheme
参考文献
Perregaard; Moltzen; Meier; Sanchez
Journal of Medicinal Chemistry, 1995 , vol. 38, # 11 p. 1998 - 2008
反应条件
1: 1.) n-BuLi / 1.) n-hexane, diethyl ether, -50 deg C, 40 min, 2.) n-hexane, diethyl ether, from -50 deg C to -10 deg C
2: 96 percent / trifluoroacetic acid / 1.5 h / Heating
3: 93 percent / 1,1,1-trichloro-ethane / 3 h / Heating
4: 93 percent / Zn (powder), acetic acid / H2O / 45 °C
View Scheme
参考文献
Perregaard; Moltzen; Meier; Sanchez
Journal of Medicinal Chemistry, 1995 , vol. 38, # 11 p. 1998 - 2008
反应条件
1: Pd(OAc)2
2: HCl
3: NaOH
View Scheme
参考文献
Chen, Jian Jeffrey; Dewdney, Nolan; Lin, Xiaohong; Martin, Robert L.; Walker, Keith A. M.; Huang, Jane; Chu, Frances; Eugui, Elsie; Mirkovich, Anna; Kim, Yong; Sarma, Keshab; Arzeno, Humberto; Van Wart, Harold E.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3951 - 3954
反应条件
1: HCl; AcOH
2: HCl
3: NaOH
View Scheme
参考文献
Chen, Jian Jeffrey; Dewdney, Nolan; Lin, Xiaohong; Martin, Robert L.; Walker, Keith A. M.; Huang, Jane; Chu, Frances; Eugui, Elsie; Mirkovich, Anna; Kim, Yong; Sarma, Keshab; Arzeno, Humberto; Van Wart, Harold E.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3951 - 3954
反应条件
1: Pd(OAc)2
2: HCl
3: NaOH
View Scheme
参考文献
Chen, Jian Jeffrey; Dewdney, Nolan; Lin, Xiaohong; Martin, Robert L.; Walker, Keith A. M.; Huang, Jane; Chu, Frances; Eugui, Elsie; Mirkovich, Anna; Kim, Yong; Sarma, Keshab; Arzeno, Humberto; Van Wart, Harold E.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3951 - 3954
反应条件
1: HCl; AcOH
2: HCl
3: NaOH
View Scheme
参考文献
Chen, Jian Jeffrey; Dewdney, Nolan; Lin, Xiaohong; Martin, Robert L.; Walker, Keith A. M.; Huang, Jane; Chu, Frances; Eugui, Elsie; Mirkovich, Anna; Kim, Yong; Sarma, Keshab; Arzeno, Humberto; Van Wart, Harold E.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3951 - 3954
反应条件
1: HCl; AcOH
2: HCl
3: NaOH
View Scheme
参考文献
Chen, Jian Jeffrey; Dewdney, Nolan; Lin, Xiaohong; Martin, Robert L.; Walker, Keith A. M.; Huang, Jane; Chu, Frances; Eugui, Elsie; Mirkovich, Anna; Kim, Yong; Sarma, Keshab; Arzeno, Humberto; Van Wart, Harold E.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3951 - 3954
