(4-甲基-1,3-噻唑-5-基)甲醇合成路线 （共 13 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=5 - 15°C; Inert atmosphere;
参考文献
ACHAOGEN, INC.; WAGMAN, Allan, Scott; MOSER, Heinz, Ernst
Patent: WO2010/30810 A1, 2010 ;
Location in patent: Page/Page column 79-80 ;
WO 2010/030810 A1
反应条件
methanol; sodium tetrahydroborate T=20 - 60°C;
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2007/87135 A2, 2007 ;
Location in patent: Page/Page column 68 ;
WO 2007/087135 A2
反应条件
1: With N,N-dimethyl-formamide in dichloromethane T=0°C; 0.5 h; 2: With methanol T=0 - 28°C; 3: With sodium tetrahydroborate T=25 - 28°C;
参考文献
ICOZEN THERAPEUTICS PVT. LTD.; RHIZEN PHARMACEUTICALS S.A.; MUTHUPPALANIAPPAN, Peyyappan; VISWANADHA, Srikant; MERIKAPUDI, Gayatri, Swaroop; VAKKALANKA, Swaroop, Kumar, V.S.
Patent: WO2011/42797 A1, 2011 ;
Location in patent: Page/Page column 70 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=5 - 15°C; 2.5 - 3.5 h; 2: With sodium sulfate in tetrahydrofuran; water
参考文献
Orchid Chemicals and Pharmaceuticals Limited
Patent: US2003/204095 A1, 2003 ;
Location in patent: Page/Page column 2 ;
反应条件
in tetrahydrofuran; ice-water
参考文献
Il-Dong Pharm. Co., Ltd.
Patent: US6063778 A1, 2000 ;
反应条件
water; bromine Behandeln des Reaktionsprodukts mit Thioformamid in Aethanol;
参考文献
Buchman; Sargent
Journal of the American Chemical Society, 1945 , vol. 67, p. 400
Full Text View citing articles Show Details
Pesina
Zhurnal Obshchei Khimii, 1939 , vol. 9, p. 804,810
Chem. Zentralbl., 1940 , vol. 111, # I p. 544
参考文献
Buchman; Sargent
Journal of the American Chemical Society, 1945 , vol. 67, p. 400
Full Text View citing articles Show Details
I.G. Farbenind.
Patent: GB456751 , 1935 ;
参考文献
Buchman; Sargent
Journal of the American Chemical Society, 1945 , vol. 67, p. 400
反应条件
Behandeln des Reaktionsprodukts mit Thioformamid in Aethanol bei Raumtemperatur und folgenden Verseifen mit 20prozentiger KOH;
参考文献
Buchman; Sargent
Journal of the American Chemical Society, 1945 , vol. 67, p. 400
反应条件
manganese(IV) oxide in toluene T=55 - 60°C; 8 - 10 h;
参考文献
Orchid Chemicals and Pharmaceuticals Limited
Patent: US2003/204095 A1, 2003 ;
Location in patent: Page/Page column 2 ;
