2-甲基-3-硝基苯甲酸合成路线 （共 60 条）
反应条件
1.1: 98 percent / H2 / Pd/C / ethanol / 20 °C 2.1: NaNO2; H2SO4 / H2O / 0 °C 2.2: 99 percent / aq. H2SO4 / Heating View Scheme
参考文献
Moreau,C.; Rouessac,F.
Bulletin de la Societe Chimique de France, 1973 , p. 3427 - 3432
反应条件
hydrogen; palladium on activated charcoal in ethanol T=20°C; Catalytic hydrogenation;
参考文献
Peixoto, Christophe; Laurin, Patrick; Klich, Michel; Dupuis-Hamelin, Claudine; Mauvais, Pascale; Lassaigne, Patrice; Bonnefoy, Alain; Musicki, Branislav
Tetrahedron Letters, 2000 , vol. 41, # 11 p. 1741 - 1745
反应条件
1: SOCl2 2: NaBH4 / tetrahydrofuran 3: SOCl2, pyridine View Scheme
参考文献
Gallagher, Gregory; Lavanchy, Patricia G.; Wilson, James W.; Hieble, J. Paul; DeMarinis, Robert M.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1533 - 1536
反应条件
1: 86 percent / sodium bicarbonate / dimethylformamide / 24 h / 60 °C 2: 86 percent / dimethylformamide / 6 h / 130 °C 3: 82 percent / hydrogen / 10percent Pd/C / benzene / 1.5 h / 2585.7 Torr 4: 97 percent / diisobutylaluminium hydride / diethyl ether; toluene / -70 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 16 p. 3350 - 3352
反应条件
Yield given. Multistep reaction;
参考文献
Heterocycles, , vol. 17, p. 417 - 423
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin; sulfuric acid T=20°C; 5 h; Product distribution / selectivity;
参考文献
Kuntz, Kevin Wayne; Campbell, John Emmerson; Seki, Masashi
Patent: US2014/107122 A1, 2014 ;
Location in patent: Paragraph 0157; 0158 ;
反应条件
1: 86 percent / sodium bicarbonate / dimethylformamide / 24 h / 60 °C 2: 86 percent / dimethylformamide / 6 h / 130 °C 3: 82 percent / hydrogen / 10percent Pd/C / benzene / 1.5 h / 2585.7 Torr 4: 97 percent / diisobutylaluminium hydride / diethyl ether; toluene / -70 °C 5: 90.4 percent / active manganese dioxide / CH2Cl2 / 48 h / Ambient temperature View Scheme
参考文献
Kozikowski; Ishida; Chen
Journal of Organic Chemistry, 1980 , vol. 45, # 16 p. 3350 - 3352
反应条件
1: H2 / Pd/C / dimethylformamide / 2223.7 Torr 2: 1.) NaNO2, HCl; 2.) KI / 1.) DMF View Scheme
参考文献
Wender, Paul A.; Dore, Timothy M.
Tetrahedron Letters, 1998 , vol. 39, # 47 p. 8589 - 8592
反应条件
1: 1,3-dibromo-5,5-dimethyl-hydantoin; sulfuric acid / 5 h / 20 °C 2: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C 3: ammonium chloride; iron / ethanol; water / 1 h / 90 °C View Scheme
参考文献
EPIZYME, INC.; EISAI CO., LTD.; KUNTZ, Kevin, Wayne; CHESWORTH, Richard; DUNCAN, Kenneth, William; KEILHACK, Heike; WARHOLIC, Natalie; KLAUS, Christine; ZHENG, Wanjun
Patent: WO2012/142513 A1, 2012 ;
WO 2012/142513 A1
反应条件
1.1: 98 percent / H2 / Pd/C / ethanol / 20 °C 2.1: NaNO2; H2SO4 / H2O / 0 °C 2.2: 99 percent / aq. H2SO4 / Heating 3.1: 100 percent / hydrogen chloride / Heating 4.1: 72 percent / K2CO3 / acetone / Heating 5.1: 100 percent / LiAlH4 / diethyl ether / 20 °C View Scheme
参考文献
Peixoto, Christophe; Laurin, Patrick; Klich, Michel; Dupuis-Hamelin, Claudine; Mauvais, Pascale; Lassaigne, Patrice; Bonnefoy, Alain; Musicki, Branislav
Tetrahedron Letters, 2000 , vol. 41, # 11 p. 1741 - 1745
