N-辛基2-乙酰氨基-2-脱氧-3-O-(beta-D-吡喃半乳糖基)-beta-D-吡喃葡萄糖苷合成路线 （共 5 条）
反应条件
1: With sodium methylate in tetrahydrofuran; methanol
96 h;
2: in tetrahydrofuran; methanol
0.333333 h;
参考文献
Hagena, Tara L.; Coward, James K.
Tetrahedron Asymmetry, 2009 , vol. 20, # 6-8 p. 781 - 794
反应条件
1: 67 percent / NIS; AgOTf / CH2Cl2 / 3 h / -70 - -50 °C
2: 75 percent / AcOH; zinc / 4 h / 20 °C
3: pyridine / 0.5 h / 20 °C
4: hydrogen / Pd(OH)2 on carbon / methanol; tetrahydrofuran
5: MeONa / methanol / 20 °C
View Scheme
参考文献
Fort, Sebastien; Kim, Hyo-Sun; Hindsgaul, Ole
Journal of Organic Chemistry, 2006 , vol. 71, # 19 p. 7146 - 7154
反应条件
1: MeONa / methanol / 0 °C
2: 3.75 g / camphorsulfonic acid / acetonitrile / 20 °C
3: 67 percent / NIS; AgOTf / CH2Cl2 / 3 h / -70 - -50 °C
4: 75 percent / AcOH; zinc / 4 h / 20 °C
5: pyridine / 0.5 h / 20 °C
6: hydrogen / Pd(OH)2 on carbon / methanol; tetrahydrofuran
7: MeONa / methanol / 20 °C
View Scheme
参考文献
Fort, Sebastien; Kim, Hyo-Sun; Hindsgaul, Ole
Journal of Organic Chemistry, 2006 , vol. 71, # 19 p. 7146 - 7154
反应条件
1: 3.08 mg / Hg(CN)2 / CH2Cl2 / 20 °C
2: MeONa / methanol / 0 °C
3: 3.75 g / camphorsulfonic acid / acetonitrile / 20 °C
4: 67 percent / NIS; AgOTf / CH2Cl2 / 3 h / -70 - -50 °C
5: 75 percent / AcOH; zinc / 4 h / 20 °C
6: pyridine / 0.5 h / 20 °C
7: hydrogen / Pd(OH)2 on carbon / methanol; tetrahydrofuran
8: MeONa / methanol / 20 °C
View Scheme
参考文献
Fort, Sebastien; Kim, Hyo-Sun; Hindsgaul, Ole
Journal of Organic Chemistry, 2006 , vol. 71, # 19 p. 7146 - 7154
反应条件
1: 3.08 mg / Hg(CN)2 / CH2Cl2 / 20 °C
2: MeONa / methanol / 0 °C
3: 3.75 g / camphorsulfonic acid / acetonitrile / 20 °C
4: 67 percent / NIS; AgOTf / CH2Cl2 / 3 h / -70 - -50 °C
5: 75 percent / AcOH; zinc / 4 h / 20 °C
6: pyridine / 0.5 h / 20 °C
7: hydrogen / Pd(OH)2 on carbon / methanol; tetrahydrofuran
8: MeONa / methanol / 20 °C
View Scheme
参考文献
Fort, Sebastien; Kim, Hyo-Sun; Hindsgaul, Ole
Journal of Organic Chemistry, 2006 , vol. 71, # 19 p. 7146 - 7154
