1-苄基-1,2,3,4-四氢异喹啉合成路线 （共 40 条）
反应条件
1: 69 percent / tetramethylethylenediamine; t-butyllithium / tetrahydrofuran / 2 h / -78 °C 2: 36 percent / hydrochloric acid / H2O / 24 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 42, # 4 p. 647 - 659
反应条件
1: 99 percent / polyphosphoric acid / 1 h / 200 - 220 °C 2: 89 percent / sodium borohydride / ethanol / 1 h / 90 °C 3: 88 percent / pyridine / 3 h / 0 °C 4: 69 percent / tetramethylethylenediamine; t-butyllithium / tetrahydrofuran / 2 h / -78 °C 5: 36 percent / hydrochloric acid / H2O / 24 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 42, # 4 p. 647 - 659
反应条件
2: P2O5 / toluene / Heating 3: NaBH4; EtOH / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 15 p. 1669 - 1671
反应条件
1: 1.) s-butyllithium / 1.) THF, 45 min, -78 deg C, 2.) 2-3 h up to -20+/-10 deg C 2: NH2NH2 / acetic acid; aq. ethanol / 12 h / 53 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 22, # 51 p. 5115 - 5118
反应条件
1: 89 percent / sodium borohydride / ethanol / 1 h / 90 °C 2: 88 percent / pyridine / 3 h / 0 °C 3: 69 percent / tetramethylethylenediamine; t-butyllithium / tetrahydrofuran / 2 h / -78 °C 4: 36 percent / hydrochloric acid / H2O / 24 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 42, # 4 p. 647 - 659
反应条件
1: (isoPrO)4Ti / 3 h / 80 °C 2: NaBH4 / methanol / 1 h / Ambient temperature 3: 99 percent / Ac2O / 1 h / 70 °C 4: 95 percent / NaIO4 / H2O; methanol / Ambient temperature 5: 1.) TFAA; 2.) BF3*Et2O / 1.) benzene, RT, 1 h; 2.) benzene, RT, 1 h 6: 89 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 7: 93 percent / aq. HCl / ethanol / 30 h / Heating View Scheme
参考文献
Heterocycles, , vol. 46, # 1 p. 555 - 565
反应条件
1: 99 percent / Ac2O / 1 h / 70 °C 2: 95 percent / NaIO4 / H2O; methanol / Ambient temperature 3: 1.) TFAA; 2.) BF3*Et2O / 1.) benzene, RT, 1 h; 2.) benzene, RT, 1 h 4: 89 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 5: 93 percent / aq. HCl / ethanol / 30 h / Heating View Scheme
参考文献
Heterocycles, , vol. 46, # 1 p. 555 - 565
反应条件
1: 95 percent / NaIO4 / H2O; methanol / Ambient temperature 2: 1.) TFAA; 2.) BF3*Et2O / 1.) benzene, RT, 1 h; 2.) benzene, RT, 1 h 3: 89 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 4: 93 percent / aq. HCl / ethanol / 30 h / Heating View Scheme
参考文献
Heterocycles, , vol. 46, # 1 p. 555 - 565
反应条件
1: 1.) TFAA; 2.) BF3*Et2O / 1.) benzene, RT, 1 h; 2.) benzene, RT, 1 h 2: 89 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 3: 93 percent / aq. HCl / ethanol / 30 h / Heating View Scheme
参考文献
Heterocycles, , vol. 46, # 1 p. 555 - 565
反应条件
1: 89 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 2: 93 percent / aq. HCl / ethanol / 30 h / Heating View Scheme
参考文献
Heterocycles, , vol. 46, # 1 p. 555 - 565
