3,4-二甲基-1H-吡咯-2-羧醛合成路线 （共 16 条）
反应条件
trichlorophosphate in diethyl ether Ambient temperature;
参考文献
Hwang, Ki-Oh; Lightner, David A.
Tetrahedron, 1991 , vol. 50, # 7 p. 1955 - 1966
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C;
参考文献
Coffin, Aaron R.; Roussell, Michael A.; Tserlin, Elina; Pelkey, Erin T.
Journal of Organic Chemistry, 2006 , vol. 71, # 17 p. 6678 - 6681
反应条件
1: hydrogen chloride; diethyl ether 2: water; NaOH-solution View Scheme
参考文献
Sugen, Inc.
Patent: US6846839 B1, 2005 ;
参考文献
Sugen, Inc.
Patent: US5834504 A1, 1998 ;
反应条件
1: 11.4 g / KOH / methanol / 2 h / Heating 2: 73 percent / POCl3 / 20 °C View Scheme
参考文献
Mikhalitsyna, Elena A.; Tyurin, Vladimir S.; Nefedov, Sergey E.; Syrbu, Sergey A.; Semeikin, Aleksandr S.; Koifman, Oskar I.; Beletskaya, Irina P.
European Journal of Inorganic Chemistry, 2012 , # 36 p. 5979 - 5990
反应条件
1: 90 percent / 180 - 190 °C 2: 73 percent / POCl3 / 20 °C View Scheme
参考文献
Dey, Sanjeev K.; Lightner, David A.
Monatshefte fur Chemie, 2008 , vol. 139, # 11 p. 1377 - 1385
参考文献
Mikhalitsyna, Elena A.; Tyurin, Vladimir S.; Nefedov, Sergey E.; Syrbu, Sergey A.; Semeikin, Aleksandr S.; Koifman, Oskar I.; Beletskaya, Irina P.
European Journal of Inorganic Chemistry, 2012 , # 36 p. 5979 - 5990
反应条件
1: 96 percent / NaOH, then H+ / ethanol / 2.) reflux 2: 1.) POCl3; 2.) NaOAc / 1.) 1,2-dichloroethane, reflux; 2.) H2O, reflux View Scheme
参考文献
Chen, Qingqi; Wang, Tianyu; Zhang, Yi; Wang, Qiuan; Ma, Jinshi
Synthetic Communications, 2002 , vol. 32, # 7 p. 1031 - 1040
反应条件
1.1: hydrogen bromide / |Reflux 2.1: benzene / 1 h / 45 °C 2.2: 1 h / |Reflux 3.1: potassium hydroxide / methanol / 2 h / |Reflux 4.1: 1.5 h / 20 °C View Scheme
参考文献
Mikhalitsyna, Elena A.; Tyurin, Vladimir S.; Nefedov, Sergey E.; Syrbu, Sergey A.; Semeikin, Aleksandr S.; Koifman, Oskar I.; Beletskaya, Irina P.
European Journal of Inorganic Chemistry, 2012 , # 36 p. 5979 - 5990
反应条件
1.1: benzene / 1 h / 45 °C 1.2: 1 h / |Reflux 2.1: potassium hydroxide / methanol / 2 h / |Reflux 3.1: 1.5 h / 20 °C View Scheme
参考文献
Chen, Qingqi; Wang, Tianyu; Zhang, Yi; Wang, Qiuan; Ma, Jinshi
Synthetic Communications, 2002 , vol. 32, # 7 p. 1031 - 1040
