3-三氟甲基-2-苯基乙酰苯胺合成路线 （共 4 条）
反应条件
triethylamine in benzene 6 h; Heating;
参考文献
Mule, A.; Pirisino, G.; Piu, L.; Satta, M.; Manca, P.; Peana, A.
Farmaco, Edizione Scientifica, 1985 , vol. 40, # 1 p. 25 - 33
反应条件
1: SOCl2 / CHCl3 / 2 h / Heating 2: 90 percent / Et3N 1 eq. / benzene / 6 h / Heating View Scheme
参考文献
Nagarajan, K.; Talwalker, P. K.; Kulkarni, C. L.; Shah, R. K.; Shenoy, S. J.; Prabhu, S. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 83 - 97
反应条件
1: 85 percent / LAH / dioxane; diethyl ether
2: 1.) benzene, reflux, 2.) ether, r.t.
3: 1.) POCl3, conc. HCl, 2.) KI / 1.) reflux, 24 h, 2.) H2O
4: NaBH4 / methanol
View Scheme
参考文献
Nagarajan, K.; Talwalker, P. K.; Kulkarni, C. L.; Shah, R. K.; Shenoy, S. J.; Prabhu, S. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 83 - 97
反应条件
1: 85 percent / LAH / dioxane; diethyl ether
2: 1.) SOCl2 / 1.) benzene, reflux, 2.) ether, r.t.
3: 1.) POCl3, conc. HCl, 2.) KI / 1.) reflux, 2.) H2O
4: NaBH4 / methanol
View Scheme
参考文献
Nagarajan, K.; Talwalker, P. K.; Kulkarni, C. L.; Shah, R. K.; Shenoy, S. J.; Prabhu, S. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 83 - 97
