1: dl-2-phenyloxetane With sec.-butyllithium in tetrahydrofuran; cyclohexane T=-78°C; 0.0833333 h; Inert atmosphere; 2: methyl iodide in tetrahydrofuran; cyclohexane T=-78°C; Inert atmosphere; regioselective reaction;

T=50°C; 72 h; Inert atmosphere;

1.1: potassium tert-butylate / tetrahydrofuran / 4 h / 25 °C 2.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / 0.08 h / -78 °C / Inert atmosphere 2.2: -78 °C / Inert atmosphere View Scheme

Yield given. Multistep reaction;

1: benzyl-N,N-dimethylamine; 2-methyl-2-phenyloxetane With sec.-butyllithium in diethyl ether; cyclohexane T=0°C; 0.25 h; Inert atmosphere; 2: methyl iodide in diethyl ether; cyclohexane regioselective reaction;