5-叠氮基-5-脱氧胸腺嘧啶脱氧核苷合成路线 （共 15 条）
反应条件
tris-(2-chloro-ethyl)-amine; triphenylphosphine; diethylazodicarboxylate in N,N-dimethyl-formamide; toluene T=40°C; 2 h;
参考文献
Hiebl, Johann; Zbiral, Erich; Balzarini, Jan; Clercq, Erik De
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1426 - 1430
反应条件
sodium azide in N,N-dimethyl-formamide T=120°C; 0.0166667 h; microwave irradiation;
参考文献
Lucas, Romain; Zerrouki, Rachida; Granet, Robert; Krausz, Pierre; Champavier, Yves
Tetrahedron, 2008 , vol. 64, # 23 p. 5467 - 5471
反应条件
lithium azide in N,N-dimethyl-formamide T=90°C; 3 h;
参考文献
Beilstein, Amy E.; Grinstaff, Mark W.
Journal of Organometallic Chemistry, 2001 , vol. 637-639, p. 398 - 406
反应条件
sodium azide in N,N-dimethyl-formamide T=80°C; 1 h; microwave irradiation;
参考文献
Lucas, Romain; Neto, Virginie; Hadj Bouazza, Amel; Zerrouki, Rachida; Granet, Robert; Krausz, Pierre; Champavier, Yves
Tetrahedron Letters, 2008 , vol. 49, # 6 p. 1004 - 1007
反应条件
anhydrous sodium hydrogen carbonate; triphenylphosphine in N-methyl-acetamide
参考文献
Europaisches Laboratorium fur Molekularbiologie (EMBL)
Patent: US6627416 B1, 2003 ;
反应条件
in N,N-dimethyl-formamide
反应条件
ammonia in methanol 16 h; Ambient temperature;
参考文献
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), , vol. 48, # 3 p. 215 - 221
反应条件
1: 94 percent / NaN3 / dimethylformamide / 4 h / 85 °C 2: 84 percent / pyridine / 26 h / 0 - 20 °C 3: trimethylsilyl triflate / acetonitrile / 24.5 h / -40 - 20 °C 4: ammonia / methanol / 16 h / Ambient temperature View Scheme
参考文献
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), , vol. 48, # 3 p. 215 - 221
反应条件
1: (NH4)2SO4 / Heating 2: trimethylsilyl triflate / acetonitrile / 24.5 h / -40 - 20 °C 3: ammonia / methanol / 16 h / Ambient temperature View Scheme
参考文献
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), , vol. 48, # 3 p. 215 - 221
反应条件
1: trimethylsilyl triflate / acetonitrile / 24.5 h / -40 - 20 °C 2: ammonia / methanol / 16 h / Ambient temperature View Scheme
参考文献
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), , vol. 48, # 3 p. 215 - 221
