1-甲基-3,5-二苯基-吡唑合成路线 （共 73 条）
反应条件
1: 5 wt Cu/Fe; hydrogenchloride / N,N-dimethyl-formamide / 3 h / 100 °C
2: N,N-dimethyl-formamide / 5 h / 100 °C
View Scheme
参考文献
Kovacs, Szabolcs; Novak, Zoltan
Tetrahedron, 2013 , vol. 69, # 43 p. 8987 - 8993
反应条件
1.1: acetic acid / ethanol / 12 h / |Reflux; |Inert atmosphere
2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / |Inert atmosphere
2.2: 5 h / 20 °C / |Reflux; |Inert atmosphere
3.1: copper(I) bromide dimethylsulfide complex; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide; caesium carbonate / 1,2-dichloro-ethane / 5 h / 135 °C / |Schlenk technique
View Scheme
参考文献
Zhang, Guangwu; Zhao, Yan; Ge, Haibo
Angewandte Chemie - International Edition, 2013 , vol. 52, # 9 p. 2559 - 2563
Angew. Chem., 2013 , vol. 125, # 9 p. 2619 - 2623,5
反应条件
1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / |Inert atmosphere
1.2: 5 h / 20 °C / |Reflux; |Inert atmosphere
2.1: copper(I) bromide dimethylsulfide complex; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide; caesium carbonate / 1,2-dichloro-ethane / 5 h / 135 °C / |Schlenk technique
View Scheme
参考文献
Zhang, Guangwu; Zhao, Yan; Ge, Haibo
Angewandte Chemie - International Edition, 2013 , vol. 52, # 9 p. 2559 - 2563
Angew. Chem., 2013 , vol. 125, # 9 p. 2619 - 2623,5
反应条件
in diethyl ether
4 h; Ambient temperature;
参考文献
Harris, D. J.; Kan, G. Y.-P.; Tschamber, T.; Snieckus, V.
Canadian Journal of Chemistry, 1980 , vol. 58, p. 494 - 500
反应条件
5 h; Ambient temperature;
参考文献
Harris, D. J.; Kan, G. Y.-P.; Tschamber, T.; Snieckus, V.
Canadian Journal of Chemistry, 1980 , vol. 58, p. 494 - 500
反应条件
in benzene
2 h; Ambient temperature;
参考文献
Harris, D. J.; Kan, G. Y.-P.; Tschamber, T.; Snieckus, V.
Canadian Journal of Chemistry, 1980 , vol. 58, p. 494 - 500
反应条件
piperidine
16 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Cross; Arotin; Ruopp
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 5 p. 905 - 910
反应条件
in benzene
9 h; Ambient temperature;
参考文献
Harris, D. J.; Kan, G. Y.-P.; Tschamber, T.; Snieckus, V.
Canadian Journal of Chemistry, 1980 , vol. 58, p. 494 - 500
参考文献
Harris, D. J.; Kan, G. Y.-P.; Tschamber, T.; Snieckus, V.
Canadian Journal of Chemistry, 1980 , vol. 58, p. 494 - 500
参考文献
Kostka, Krzysztof; Strawiak, Marian M.
Polish Journal of Chemistry, 1984 , vol. 58, # 7-8-9 p. 647 - 651
