1-甲基-3,5-二苯基-吡唑合成路线 （共 73 条）
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: 1 h / 0 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Tinarelli, Alessandro; Righi, Paolo; Rosini, Goffredo; Andreotti, Daniele; Profeta, Roberto; Spada, Simone
Tetrahedron, 2011 , vol. 67, # 3 p. 612 - 617
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: 0.5 h / 0 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Tinarelli, Alessandro; Righi, Paolo; Rosini, Goffredo; Andreotti, Daniele; Profeta, Roberto; Spada, Simone
Tetrahedron, 2011 , vol. 67, # 3 p. 612 - 617
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: 0.33 h / -10 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Tinarelli, Alessandro; Righi, Paolo; Rosini, Goffredo; Andreotti, Daniele; Profeta, Roberto; Spada, Simone
Tetrahedron, 2011 , vol. 67, # 3 p. 612 - 617
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: 1 h / 0 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Tinarelli, Alessandro; Righi, Paolo; Rosini, Goffredo; Andreotti, Daniele; Profeta, Roberto; Spada, Simone
Tetrahedron, 2011 , vol. 67, # 3 p. 612 - 617
参考文献
Cross; Arotin; Ruopp
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 5 p. 905 - 910
参考文献
Cross; Arotin; Ruopp
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 5 p. 905 - 910
反应条件
in methanol; acetic acid
24 h; Ambient temperature;
参考文献
Fliege, Werner; Grashey, Rudolf; Huisgen, Rolf
Chemische Berichte, 1984 , vol. 117, # 3 p. 1194 - 1214
反应条件
in benzene
6 h; Ambient temperature;
参考文献
Harris, D. J.; Kan, G. Y.-P.; Tschamber, T.; Snieckus, V.
Canadian Journal of Chemistry, 1980 , vol. 58, p. 494 - 500
反应条件
1: 72 percent / Et3N / benzene / 4 h / Heating
2: 54 percent / chloranil / xylene / 6 h / Heating
View Scheme
参考文献
Fliege, Werner; Grashey, Rudolf; Huisgen, Rolf
Chemische Berichte, 1984 , vol. 117, # 3 p. 1194 - 1214
反应条件
1.1: acetic acid / ethanol / 12 h / |Reflux; |Inert atmosphere
2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / |Inert atmosphere
2.2: 5 h / 20 °C / |Reflux; |Inert atmosphere
3.1: copper(I) bromide dimethylsulfide complex; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide; caesium carbonate / 1,2-dichloro-ethane / 5 h / 135 °C / |Schlenk technique
View Scheme
参考文献
Zhang, Guangwu; Zhao, Yan; Ge, Haibo
Angewandte Chemie - International Edition, 2013 , vol. 52, # 9 p. 2559 - 2563
Angew. Chem., 2013 , vol. 125, # 9 p. 2619 - 2623,5
