2,2-二氟-2-(甲硫基)-1-苯乙酮合成路线 （共 6 条）
反应条件
1-Fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; zinc dibromide in trichloroethane, 1,1,2- T=80 - 105°C;
参考文献
Eto; Kaneko; Takeda; Tokizawa; Sato; Yoshida; Namiki; Ogawa; Maebashi; Ishida; Matsumoto; Asaoka
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 2 p. 173 - 182
参考文献
SS Pharmaceutical Co., Ltd.
Patent: US5945438 A1, 1999 ;
反应条件
in dimethyl sulfoxide T=20°C; 15 h;
参考文献
Eto; Kaneko; Takeda; Tokizawa; Sato; Yoshida; Namiki; Ogawa; Maebashi; Ishida; Matsumoto; Asaoka
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 2 p. 173 - 182
反应条件
1: 73 percent / dimethylsulfoxide / 15 h / 20 °C 2: 82 percent / N-fluoro-2,4,6-trimethylpyridinium triflate; zinc bromide / 1,1,2-trichloro-ethane / 80 - 105 °C View Scheme
参考文献
Eto; Kaneko; Takeda; Tokizawa; Sato; Yoshida; Namiki; Ogawa; Maebashi; Ishida; Matsumoto; Asaoka
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 2 p. 173 - 182
反应条件
1: H2O; methanol / 1 h / 20 °C 2: 75.9 percent / N-fluoro-2,4,6-trimethylpyridinium triflate; ZnBr2 / 1,1,2-trichloro-ethane / 1.5 h / 105 °C View Scheme
参考文献
Takeda, Sunao; Kaneko, Yasushi; Eto, Hiromichi; Tokizawa, Minoru; Sato, Susumu; Yoshida, Kouiti; Namiki, Setsuo; Ogawa, Masaki
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 7 p. 1097 - 1100
反应条件
1: trimethyl-oxo-sulfonium iodide With sodium hydride in tetrahydrofuran; dimethyl sulfoxide T=20°C; 1 h; 2: 2,2-difluoro-2-(methylthio)acetophenone in tetrahydrofuran; dimethyl sulfoxide T=0°C; 1 h;
参考文献
Eto; Kaneko; Takeda; Tokizawa; Sato; Yoshida; Namiki; Ogawa; Maebashi; Ishida; Matsumoto; Asaoka
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 2 p. 173 - 182
