(S)-N-[(2S,4S,5S)-5-氨基-4-羟基-1,6-二苯基己烷-2-基]-3-甲基-2-(2-氧代四氢嘧啶-1(2H)-基)丁酰胺合成路线

192726-04-8(S)-N-[(2S,4S,5S)-5-(二苄基氨基)-4-羟基-1,6-二苯基己烷-2-基]-3-甲基-2-(2-氧代四氢嘧啶-1(2H)-基)丁酰胺

192726-05-9(S)-N-[(2S,4S,5S)-5-氨基-4-羟基-1,6-二苯基己烷-2-基]-3-甲基-2-(2-氧代四氢嘧啶-1(2H)-基)丁酰胺

参考文献

Abbott Laboratories
Patent: EP1170289 A2, 2002 ;
Location in patent: Page 65 ;

192800-77-4(S)-四氢-alpha-(1-甲基乙基)-2-氧代-

192726-05-9(S)-N-[(2S,4S,5S)-5-氨基-4-羟基-1,6-二苯基己烷-2-基]-3-甲基-2-(2-氧代四氢嘧啶-1(2H)-基)丁酰胺

参考文献

Reddy, G. S. Kiran Kumar; Ali, Akbar; Nalam, Madhavi N. L.; Anjum, Saima Ghafoor; Cao, Hong; Nathans, Robin S.; Schiffer, Celia A.; Rana, Tariq M.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 18 p. 4316 - 4328

192725-50-1(2S)-(1-四氢嘧啶-2-酮)-3-甲基丁酸

192726-05-9(S)-N-[(2S,4S,5S)-5-氨基-4-羟基-1,6-二苯基己烷-2-基]-3-甲基-2-(2-氧代四氢嘧啶-1(2H)-基)丁酰胺

参考文献

Reddy, G. S. Kiran Kumar; Ali, Akbar; Nalam, Madhavi N. L.; Anjum, Saima Ghafoor; Cao, Hong; Nathans, Robin S.; Schiffer, Celia A.; Rana, Tariq M.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 18 p. 4316 - 4328

156732-15-9(2S,3S,5S)-5-氨基-2-(二苄基氨基)-1,6-二苯基己-3-醇

192726-05-9(S)-N-[(2S,4S,5S)-5-氨基-4-羟基-1,6-二苯基己烷-2-基]-3-甲基-2-(2-氧代四氢嘧啶-1(2H)-基)丁酰胺

参考文献

Reddy, G. S. Kiran Kumar; Ali, Akbar; Nalam, Madhavi N. L.; Anjum, Saima Ghafoor; Cao, Hong; Nathans, Robin S.; Schiffer, Celia A.; Rana, Tariq M.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 18 p. 4316 - 4328

402712-50-9+

156732-15-9(2S,3S,5S)-5-氨基-2-(二苄基氨基)-1,6-二苯基己-3-醇

192726-05-9(S)-N-[(2S,4S,5S)-5-氨基-4-羟基-1,6-二苯基己烷-2-基]-3-甲基-2-(2-氧代四氢嘧啶-1(2H)-基)丁酰胺

参考文献

Abbott Laboratories
Patent: US6372905 B1, 2002 ;
Location in patent: Example 3 ;

192726-05-9(S)-N-[(2S,4S,5S)-5-氨基-4-羟基-1,6-二苯基己烷-2-基]-3-甲基-2-(2-氧代四氢嘧啶-1(2H)-基)丁酰胺+

20143-48-0(2,6-二甲基苯氧基)乙酰氯

192725-17-0洛匹那韦

参考文献

Abbott Laboratories
Patent: EP1170289 A2, 2002 ;
Location in patent: Page 25 ;