(2S)-(1-四氢嘧啶-2-酮)-3-甲基丁酸合成路线 （共 12 条）
反应条件
1: thionyl chloride / tetrahydrofuran / 5.5 h / 4 - 20 °C / |Inert atmosphere 2: 1H-imidazole / ethyl acetate; N,N-dimethyl-formamide / 2 - 30 °C / |Inert atmosphere 3: 5 palladium on charcoal; ammonium formate / methanol / 50 °C / |Inert atmosphere 4: 1,4-dioxane / 1 h / 20 - 50 °C / |Inert atmosphere 5: sodium hydrogencarbonate / ethyl acetate; water / 0.58 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Stoner, Eric J.; Cooper, Arthur J.; Dickman, Daniel A.; Kolaczkowski, Lawrence; Lallaman, John E.; Liu, Jih-Hua; Oliver-Shaffer, Patricia A.; Patel, Ketan M.; Paterson Jr., Joseph B.; Plata, Daniel J.; Riley, David A.; Sham, Hing L.; Stengel, Peter J.; Tien, Jien-Heh J.
Organic Process Research and Development, 2000 , vol. 4, # 4 p. 264 - 269
反应条件
thionyl chloride in tetrahydrofuran T=4 - 20°C; 5.5 h; Inert atmosphere;
参考文献
Stoner, Eric J.; Stengel, Peter J.; Cooper, Arthur J.
Organic Process Research and Development, 1999 , vol. 3, # 2 p. 145 - 148
