4-溴-N-甲氧基-N-甲基苯胺合成路线 （共 19 条）
反应条件
in tetrahydrofuran T=0°C; Grignard reaction; 3 h;
参考文献
Hu, Yonghan; Baudart, Sylvie; Porco Jr., John A.
Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1049 - 1051
反应条件
in tetrahydrofuran T=0°C; Grignard reaction; 3 h;
参考文献
Hu, Yonghan; Baudart, Sylvie; Porco Jr., John A.
Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1049 - 1051
反应条件
1: 4-Methylpyridine With lithium diisopropyl amide in tetrahydrofuran T=0°C; 0.5 h; Inert atmosphere; 2: N-methoxy-N-methyl-p-bromobenzamide in tetrahydrofuran T=-65°C; 1.25 h; Inert atmosphere;
参考文献
SU ZHOU JING HONG BIOTECH CO., LTD.; CAI, Zhen-Wei; ZHOU, Ding; LIN, Yougang; CHEN, Ping
Patent: US2013/158031 A1, 2013 ;
Location in patent: Paragraph 0180; 0181 ;
反应条件
in tetrahydrofuran T=0°C; Grignard reaction; 3 h;
参考文献
Hu, Yonghan; Baudart, Sylvie; Porco Jr., John A.
Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1049 - 1051
反应条件
1: vinyl-magnesium bromide; N-methoxy-N-methyl-p-bromobenzamide in tetrahydrofuran 2: dimethyl amine in tetrahydrofuran
参考文献
Lee, Ki-Ho; Park, Chun-Eung; Min, Kyung-Hyun; Shin, Yong-Je; Chung, Coo-Min; Kim, Hui-Ho; Yoon, Hae-Jeoung; Won-Kim; Ryu, Eun-Ju; Shin, Yu-Jin; Nam, Hyun-Sik; Cho, Jeong-Woo; Lee, Hee-Yoon
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 18 p. 5567 - 5571
反应条件
1: 1-bromo-3-fluoro-4-methoxybenzene With n-butyllithium in tetrahydrofuran; hexanes T=-78°C; 1 h; 2: N-methoxy-N-methyl-p-bromobenzamide in tetrahydrofuran; hexanes T=-20°C; 1 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/12220 A2, 2005 ;
Location in patent: Page/Page column 80-81 ;
WO 2005/012220 A2
反应条件
1: meta-dibromobenzene With iodine; magnesium in diethyl ether
T=20 - 30°C; Inert atmosphere;
2: N-methoxy-N-methyl-p-bromobenzamide in diethyl ether
T=0 - 20°C; Inert atmosphere;
参考文献
Kishore Kumar; Chavarria, Gustavo E.; Charlton-Sevcik, Amanda K.; Arispe, Wara M.; MacDonough, Matthew T.; Strecker, Tracy E.; Chen, Shen-En; Siim, Bronwyn G.; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 4 p. 1415 - 1419
反应条件
1.1: tetrahydrofuran / 3 h / 0 °C
2.1: polystyrene-sulfonylhydrazide resin; acetic acid / tetrahydrofuran / 4 h / 50 °C
2.2: Pd(PPh3)2Cl2 / dimethylformamide / 24 h / 90 °C
2.3: 80 percent / thionyl chloride / 1,2-dichloro-ethane / 5 h / 60 °C
View Scheme
参考文献
Hu, Yonghan; Baudart, Sylvie; Porco Jr., John A.
Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1049 - 1051
反应条件
in tetrahydrofuran
T=0°C; 1.1666 h;
参考文献
Wyeth
Patent: US2007/66675 A1, 2007 ;
Location in patent: Page/Page column 16 ;
