5-甲基-1H-吲唑-3-羧酸乙酯合成路线 （共 3 条）
反应条件
potassium fluoride; 18-crown-6 ether in tetrahydrofuran T=20°C; 24 h; Title compound not separated from byproducts.;
参考文献
Jin, Tienan; Yang, Fan; Yamamoto, Yoshinori
Collection of Czechoslovak Chemical Communications, 2009 , vol. 74, # 6 p. 957 - 972
反应条件
1.1: sodium hydroxide / water / 0.5 h / 50 °C 1.2: 1 h / 0 °C 1.3: 18 h / 0 - 20 °C 2.1: sulfuric acid / 5 h / 100 °C View Scheme
参考文献
Crocetti, Letizia; Schepetkin, Igor A.; Cilibrizzi, Agostino; Graziano, Alessia; Vergelli, Claudia; Giomi, Donatella; Khlebnikov, Andrei I.; Quinn, Mark T.; Giovannoni, Maria Paola
Journal of Medicinal Chemistry, 2013 , vol. 56, # 15 p. 6259 - 6272
反应条件
sulfuric acid T=100°C; 5 h;
参考文献
Crocetti, Letizia; Schepetkin, Igor A.; Cilibrizzi, Agostino; Graziano, Alessia; Vergelli, Claudia; Giomi, Donatella; Khlebnikov, Andrei I.; Quinn, Mark T.; Giovannoni, Maria Paola
Journal of Medicinal Chemistry, 2013 , vol. 56, # 15 p. 6259 - 6272
