1: MeMgX With copper(l) iodide in tetrahydrofuran T=20°C; 2: dimethyl glutaconate With chloro-trimethyl-silane in tetrahydrofuran T=-78 - 20°C; Michael addition;
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 10 p. 3522 - 3535
1: (R)-5-methyl-2-(1-methylethyl)-2-cyclohexen-1-one With ozone in dichloromethane T=-65°C; 2: methanol With toluene-4-sulfonic acid in dichloromethane T=20°C; 48 h;
参考文献
Russian Journal of Organic Chemistry, , vol. 38, # 7 p. 1005 - 1008