1: 4-benzyl-benzoic acid With oxalyl dichloride in dichloromethane T=20°C; 3 h; 2: ethanol With triethylamine T=20°C; 16 h;

1: benzyl bromide With zinc in tetrahydrofuran T=0°C; 2 h; 2: ethyl 4-hydroxybenzoate O-trifalte With 1,1'-bis-(diphenylphosphino)ferrocene; tetra-(n-butyl)ammonium iodide; bis(dibenzylideneacetone) palladium in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=60°C; 4 h; Further stages.;

N,N,N',N,-tetramethylethylenediamine; mono(bis(di-tert-butyl(4-(dimethylamino)phenyl)phosphonio)palladium(II))dichloride; zinc in water T=20°C; 8 h; Inert atmosphere;

N,N,N',N,-tetramethylethylenediamine; mono(bis(di-tert-butyl(4-(dimethylamino)phenyl)phosphonio)palladium(II))dichloride; zinc in water T=20°C; 8 h; Inert atmosphere;

1: benzyl bromide With manganese in tetrahydrofuran T=20°C; Metallation; 0.333333 h; 2: 4-iodobenzoic acid ethyl ester With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=20°C; Substitution;

[bdmim][BF4]; 1-butyl-2-(diphenylphosphanyl)-3-methylimidazolium hexafluorophosphate; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran; toluene T=20°C; Substitution; Negishi cross-coupling reaction; 18 h;

1: Merrifield resin-CH2O(CH2)4S-CH2C6H4-C(O)OEt-4 With triethyloxonium tetra-fluoroborate in dichloromethane T=20°C; Solid phase reaction; Alkylation the sulfur atom; 8 h; 2: 3,4,5-trimethoxyphenylboronic acid With potassium carbonate; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) in tetrahydrofuran T=60°C; Arylation; Cleavage from the resin; 14 h;

N,N,N',N,-tetramethylethylenediamine; mono(bis(di-tert-butyl(4-(dimethylamino)phenyl)phosphonio)palladium(II))dichloride; zinc in water T=20°C; 8 h; Inert atmosphere;

dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; potassium phosphate in tetrahydrofuran; N,N-dimethyl-formamide T=60°C; Suzuki-Miyaura reaction; 2 h;

1: 4-iodobenzoic acid ethyl ester With isopropylmagnesium chloride in tetrahydrofuran; ethylene glycol dimethyl ether T=-20°C; 0.333333 h; 2: With copper(l) chloride; triethyl phosphite in tetrahydrofuran; ethylene glycol dimethyl ether T=-15°C; 0.166667 h; 3: BnOP(O)(OEt)2 With tetra-(n-butyl)ammonium iodide in tetrahydrofuran; ethylene glycol dimethyl ether T=60°C; 1.5 h;