2-甲基-2-(苯氧基)丙酸乙酯合成路线 （共 15 条）
反应条件
caesium carbonate in DMF (N,N-dimethyl-formamide) T=60°C;
参考文献
KALYPSYS, INC.
Patent: WO2004/92117 A1, 2004 ;
Location in patent: Page 51 ;
WO 2004/092117 A1
反应条件
hydrogen; triethylamine; palladium on activated charcoal in methanol T=20°C; 27 h;
参考文献
Sajiki, Hironao; Kume, Akira; Hattori, Kazuyuki; Hirota, Kosaku
Tetrahedron Letters, 2002 , vol. 43, # 40 p. 7247 - 7250
Title/Abstract Full Text View citing articles Show Details
Monguchi, Yasunari; Kume, Akira; Hattori, Kazuyuki; Maegawa, Tomohiro; Sajiki, Hironao
Tetrahedron, 2006 , vol. 62, # 33 p. 7926 - 7933
反应条件
1: 1,1,1-trichloro-2-methyl-2-propanol; phenol With sodium hydroxide in acetone T=20°C; 2: ethanol With thionyl chloride 6 h; Heating;
参考文献
Tanaka; Tamai; Mukaiyama; Hirabayashi; Muranaka; Ishikawa; Akahane
Bioorganic and medicinal chemistry, 2001 , vol. 9, # 12 p. 3265 - 3271
反应条件
1: 1-methyl-2,3-indolinedione With sodium amalgam in N,N-dimethyl-formamide T=20°C; 4 h; 2: ethyl 2-(2-iodophenoxy)-2-methylpropanoate in N,N-dimethyl-formamide T=110°C; 18 h;
参考文献
Sword, Ryan; O'Sullivan, Steven; Murphy, John A.
Australian Journal of Chemistry, 2013 , vol. 66, # 3 p. 314 - 322
反应条件
T=20°C; 36.5 h; Heating / reflux;
参考文献
Yao, Wenqing; Xu, Meizhong; Zhang, Colin; Agrios, Konstantinos; Metcalf, Brian W.; Zhuo, Jincong
Patent: US2006/9471 A1, 2006 ;
Location in patent: Page/Page column 43 ;
反应条件
copper diacetate; α-cyclohexylcyclohexanemethanamine in dichloromethane T=20°C; 3 h; Product distribution; Further Variations:Reaction partners;
参考文献
Ikegai, Kazuhiro; Fukumoto, Kentarou; Mukaiyama, Teruaki
Chemistry Letters, 2006 , vol. 35, # 6 p. 612 - 613
反应条件
copper diacetate; α-cyclohexylcyclohexanemethanamine in dichloromethane T=20°C; 3 h; Product distribution; Further Variations:Reagents;
参考文献
Ikegai, Kazuhiro; Fukumoto, Kentarou; Mukaiyama, Teruaki
Chemistry Letters, 2006 , vol. 35, # 6 p. 612 - 613
参考文献
Bischoff
Chemische Berichte, 1900 , vol. 33, p. 930
参考文献
Bargellini
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1906 , vol. <5> 15 I, p. 585
Gazzetta Chimica Italiana, 1906 , vol. 36 II, p. 336
反应条件
(i) NaOH, (ii) (esterification); Multistep reaction;
参考文献
Witiak; Ho; Hackney; Connor
Journal of medicinal chemistry, 1968 , vol. 11, # 5 p. 1086 - 1089
