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1: glacial acetic acid; nitric acid 2: concentrated sulfuric acid View Scheme

buffer solution; pilocarpine; 2(3H)-furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)-methyl] monohydrochloride, (3S-cis) in water; acetonitrile T=24.9°C; other catalysts, var. pH-values; Rate constant;