1-(3,4-二甲氧基苯基)-1-丙酮合成路线 （共 42 条）
参考文献
Gazzetta Chimica Italiana, , vol. 42 II, p. 347
反应条件
1: NH2OH*HCl; NaOAc / methanol / 18 h / 20 °C 2: H2; thiophene; NH3 / RaNi / methanol View Scheme
参考文献
Van Lommen, Guy; Doyon, Julien; Coesemans, Erwin; Boeckx, Staf; Cools, Marina; Buntinx, Mieke; Hermans, Bart; VanWauwe, Jean
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 3 p. 497 - 500
反应条件
T=210°C; und Erhitzen des Reaktionsprodukts mit wss.Salzsaeure;
参考文献
Norcross; Openshaw
Journal of the Chemical Society, 1949 , p. 1174,1178
反应条件
bromine in chloroform T=62 - 64°C; 0.916667 h; Inert atmosphere;
参考文献
Li, Xu; Jiang, Jian-Hong; Chen, Qingqi; Xiao, Sheng-Xiong; Li, Chuan-Hua; Gu, Hui-Wen; Zhang, Hui; Hu, Ji-Lin; Yao, Fei-Hong; Li, Qiang-Guo
European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 605 - 613
反应条件
1: benzene; sulfur / 130 °C 2: aqueous KOH-solution View Scheme
参考文献
Kindler; Li
Chemische Berichte, 1941 , vol. 74, p. 321,324
反应条件
lithium aluminium tetrahydride in diethyl ether Reduction; 8 h; Heating;
参考文献
Zacchino, Susana A.; Lopez, Silvia N.; Pezzenati, German D.; Furlan, Ricardo L.; Santecchia, Carina B.; Munoz, Lorena; Giannini, Fernando A.; Rodriguez, Ana M.; Enriz, Ricardo D.
Journal of Natural Products, 1999 , vol. 62, # 10 p. 1353 - 1357
反应条件
hydrogenchloride; amalgamated zinc
参考文献
Hewgill, Frank R.; Pass, Michael C.
Australian Journal of Chemistry, 1985 , vol. 38, # 4 p. 555 - 563
参考文献
Johnson; Hodge
Journal of the American Chemical Society, 1913 , vol. 35, p. 1019
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 - 7 °C / |Inert atmosphere 1.2: 0.28 h / 18 °C 1.3: 0.67 h / -70 - -55 °C 2.1: hydrogenchloride / methanol / 6.5 h / 44 - 54 °C / |Inert atmosphere; |Large scale 3.1: palladium 10 on activated carbon; hydrogen / 1-Propyl acetate / 8 h / 100 °C / 51716.2 Torr View Scheme
参考文献
Li, Xu; Jiang, Jian-Hong; Chen, Qingqi; Xiao, Sheng-Xiong; Li, Chuan-Hua; Gu, Hui-Wen; Zhang, Hui; Hu, Ji-Lin; Yao, Fei-Hong; Li, Qiang-Guo
European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 605 - 613
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 - 7 °C / |Inert atmosphere 1.2: 0.28 h / 18 °C 1.3: 0.67 h / -70 - -55 °C 2.1: hydrogenchloride / methanol / 6.5 h / 44 - 54 °C / |Inert atmosphere; |Large scale 3.1: palladium 10 on activated carbon; hydrogen / 1-Propyl acetate / 3 h / 100 °C / 51716.2 Torr View Scheme
参考文献
Li, Xu; Jiang, Jian-Hong; Chen, Qingqi; Xiao, Sheng-Xiong; Li, Chuan-Hua; Gu, Hui-Wen; Zhang, Hui; Hu, Ji-Lin; Yao, Fei-Hong; Li, Qiang-Guo
European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 605 - 613
