1-甲基-4-(1-环己烯基)苯合成路线 （共 31 条）
反应条件
C31H23Cl2N2NiP in tetrahydrofuran
T=30°C; Kumada Cross-Coupling; 12 h; Schlenk techniqueInert atmosphere;
参考文献
Zhang, Xue-Qi; Wang, Zhong-Xia
Synlett, 2013 , vol. 24, # 16 art. no. ST-2013-W0528-L, p. 2081 - 2084
反应条件
palladium dichloride in tetrahydrofuran
T=20°C; Kumada-Corriu coupling; 7 h; Inert atmosphere;
参考文献
Gauthier, Delphine; Beckendorf, Stephan; Gogsig, Thomas M.; Lindhardt, Anders T.; Skrydstrup, Troels
Journal of Organic Chemistry, 2009 , vol. 74, # 9 p. 3536 - 3539
反应条件
1: (4-Methylphenyl)-magnesium bromide With [Ni0(1,5-cyclooctadiene)2]; SIDip*HCl in tetrahydrofuran
T=0°C; 0.166667 h;
2: (cyclohexylsulfanyl)benzene in tetrahydrofuran
T=0 - 60°C; 6.16667 h;
参考文献
Ishizuka, Kentaro; Seike, Hirofumi; Hatakeyama, Takuji; Nakamura, Masaharu
Journal of the American Chemical Society, 2010 , vol. 132, # 38 p. 13117 - 13119
反应条件
bis(acetylacetonate)nickel(II); P(t-Bu)2Me in diethyl ether; toluene
20 h; Heating;
参考文献
Huang, Li-Fu; Huang, Chih-Hao; Stulgies, Baldur; De Meijere, Armin; Luh, Tien-Yau
Organic Letters, 2003 , vol. 5, # 23 p. 4489 - 4491
反应条件
1: 1.) Mg / 1.) THF, room t., 2.) THF, room t., 1 h
2: p-TsOH / benzene / 16 h / Heating
View Scheme
参考文献
Kametani, Tetsuji; Kawamura, Kuniaki; Tsubuki, Masayoshi; Honda, Toshio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 193 - 200
反应条件
1.1: t-BuLi / tetrahydrofuran / -78 °C
1.2: tetrahydrofuran / 0.5 h / -78 °C
2.1: H2SO4; AcOH / 0.5 h / 0 °C
View Scheme
参考文献
Nakamura, Shingo; Kaneeda, Masanobu; Ishihara, Kazuaki; Yamamoto, Hisashi
Journal of the American Chemical Society, 2000 , vol. 122, # 34 p. 8120 - 8130
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate in N,N-dimethyl-formamide
T=80°C; Suzuki-Miyaura coupling; 17 h; Inert atmosphere;
参考文献
Kondoh, Azusa; Jamison, Timothy F.
Chemical Communications, 2010 , vol. 46, # 6 p. 907 - 909
反应条件
1,2-dimethoxy-benzene; Pd(F6-acac)2; 1,3-bis-(diphenylphosphino)propane; lithium carbonate
T=120°C; Heck Reaction; 48 h; Inert atmosphere;
参考文献
Wu, Xiaojin; Lu, Yunpeng; Hirao, Hajime; Zhou, Jianrong
Chemistry - A European Journal, 2013 , vol. 19, # 19 p. 6014 - 6020
反应条件
(i) Mg, Et2O, (ii) /BRN= 385735/, (iii) TsOH, benzene; Multistep reaction;
参考文献
Davies,M.T. et al.
Tetrahedron, 1962 , vol. 18, p. 751 - 761
反应条件
tetrakis(triphenylphosphine) palladium(0) in benzene
T=80°C; 24 h;
参考文献
Kamigata, Nobumasa; Satoh, Akira; Kondoh, Tetsuya; Kameyama, Masayuki
Bulletin of the Chemical Society of Japan, 1988 , vol. 61, p. 3575 - 3580
