in tetrahydrofuran T=20°C; Inert atmosphere;

in N,N-dimethyl-formamide T=25°C; different concentrations of imidazole; Equilibrium constantRate constant;

in N,N-dimethyl-formamide T=25°C; different concentrations of imidazole; Equilibrium constantRate constant;

in dichloromethane 16 h; Inert atmosphere;

1: propanedioic acid monoethyl ester With iso-propylmagnesium bromide in tetrahydrofuran T=0 - 40°C; 2: tert-butyloxycarbonylglycine imidazolide in tetrahydrofuran T=0 - 20°C; 3: With water; sodium hydrogencarbonate in tetrahydrofuran T=0°C;

1: malonic acid ethyl ester monopotassium salt With triethylamine; magnesium chloride T=20°C; 4 h; 2: tert-butyloxycarbonylglycine imidazolide T=20°C; 16 h;