4-苯基-3-丁炔-2-酮合成路线 （共 131 条）
反应条件
1: phenylacetylene With n-butyllithium in tetrahydrofuran; hexane T=0°C; 0.5 h; Inert atmosphere; 2: ethyl acetate With boron trifluoride diethyl etherate in tetrahydrofuran; hexane T=-78°C; 0.5 h; Inert atmosphere; 3: With water; ammonium chloride in tetrahydrofuran; hexane T=-78 - 20°C;
参考文献
Schuler, Marie; Silva, Franck; Bobbio, Carla; Tessier, Arnaud; Gouverneur, Veronique
Angewandte Chemie - International Edition, 2008 , vol. 47, # 41 p. 7927 - 7930
反应条件
(8-oxyquinolinate)2VV(O)(OiPr); triethylamine in 1,2-dichloro-ethane T=60°C; 24 h;
参考文献
Hanson, Susan K.; Wu, Ruilian; Silks, L. A. Pete
Organic Letters, 2011 , vol. 13, # 8 p. 1908 - 1911
反应条件
1: phenylacetylene With ethyl bromide; iodine; magnesium in tetrahydrofuran T=35°C; Large scale; 2: acetic anhydride in tetrahydrofuran T=4°C; 2 h; Large scale; Temperature;
参考文献
Zanka, Atsuhiko
Organic Process Research and Development, 1998 , vol. 2, # 1 p. 60 - 62
反应条件
tert.-butylhydroperoxide; FePcS-SiO2 in chlorobenzene; tert-butyl alcohol T=40°C; 24 h;
参考文献
Perollier, Celine; Pergrale-Mejean, Corinne; Sorokin, Alexander B.
New Journal of Chemistry, 2005 , vol. 29, # 11 p. 1400 - 1403
反应条件
1: phenylacetylene With n-butyllithium 2: With zinc(II) chloride 3: acetyl chloride
参考文献
Gao, Meng; Yin, Guodong; Wang, Zihua; Wu, Yandong; Guo, Cheng; Pan, Yuanjiang; Wu, Anxin
Tetrahedron, 2009 , vol. 65, # 31 p. 6047 - 6049
反应条件
tert.-butylhydroperoxide; tetrabutyl-ammonium chloride; BQC; sodium carbonate in water T=20°C; 24 h;
参考文献
Nait Ajjou, Abdelaziz; Ferguson, Gabriel
Tetrahedron Letters, 2006 , vol. 47, # 22 p. 3719 - 3722
反应条件
tetrabutyl-ammonium chloride; sodium carbonate; BQC; CUCl2*2H2O in water T=20°C; 24 h;
参考文献
Nait Ajjou, Abdelaziz; Ferguson, Gabriel
Tetrahedron Letters, 2006 , vol. 47, # 22 p. 3719 - 3722
反应条件
1: tri-phenyl-antimony With [bis(acetoxy)iodo]benzene in dichloromethane T=20°C; 7 h; 2: 4-(trimethylsilyl)-3-butyn-2-one With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; copper(l) iodide in acetonitrile T=50°C; 5 h; Further stages.;
参考文献
Kang, Suk-Ku; Ryu, Hyung-Chul; Hong, Young-Taek
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 7 p. 736 - 739
反应条件
copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride in acetonitrile T=60°C; 14 h;
参考文献
Oh, Chang Ho; Reddy, V. Raghava
Tetrahedron Letters, 2004 , vol. 45, # 46 p. 8545 - 8548
反应条件
bis-triphenylphosphine-palladium(II) chloride in 1,2-dichloro-ethane T=84°C; 2 h;
参考文献
Logue, Marshall W.; Teng, Kelly
Journal of Organic Chemistry, 1982 , vol. 47, # 13 p. 2549 - 2553
