pyridine T=20°C; Tosylation;

1: 52 percent / aq. HCl; phosphoric acid / 3 h / 95 °C 2: 54 percent / diisopropylethylamine / ethanol / 24 h / Heating 3: 86 percent / H2 / 5 percent Pd/C / ethanol / 24 h / 20 °C 4: 85 percent / pyridine / 20 °C View Scheme

1: 54 percent / diisopropylethylamine / ethanol / 24 h / Heating 2: 86 percent / H2 / 5 percent Pd/C / ethanol / 24 h / 20 °C 3: 85 percent / pyridine / 20 °C View Scheme

1: 86 percent / H2 / 5 percent Pd/C / ethanol / 24 h / 20 °C 2: 85 percent / pyridine / 20 °C View Scheme

sodium hydride in tetrahydrofuran

lithium hydroxide in tetrahydrofuran; methanol Hydrolysis; 4 h; Heating;