(E)-3-(吡啶-2-基)丙烯酸叔丁酯合成路线 （共 7 条）
反应条件
1,4-diaza-bicyclo[2.2.2]octane; potassium carbonate; palladium diacetate in N,N-dimethyl-formamide T=120°C; Heck cross-coupling reaction; 24 h;
参考文献
Li, Jin-Heng; Wang, De-Ping; Xie, Ye-Xiang
Synthesis, 2005 , # 13 art. no. F03805SS, p. 2193 - 2197
反应条件
triphenylphosphine; nanocrystalline aerogel prepared MgO in N,N-dimethyl-formamide T=20°C; Wittig reaction; 6 h;
参考文献
Choudary, Boyapati M.; Mahendar, Koosam; Kantam, M. Lakshmi; Ranganath, Kalluri V. S.; Athar, Taimur
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 14 p. 1977 - 1985
反应条件
1: t-butyl 2-(diethoxyphosphoryl)acetate With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2: pyridine-2-carbaldehyde in tetrahydrofuran; hexane T=-78 - 20°C; Wittig reaction; Further stages.;
参考文献
Bull, Steven D.; Davies, Stephen G.; Fox, David J.; Gianotti, Massimo; Kelly, Peter M.; Pierres, Camille; Savory, Edward D.; Smith, Andrew D.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 16 p. 1858 - 1868
反应条件
tetrahydroxydiboron in N,N-dimethyl-formamide; acetonitrile T=20°C; 0.166667 h;
参考文献
Londregan, Allyn T.; Piotrowski, David W.; Xiao, Jun
Synlett, 2013 , vol. 24, # 20 art. no. ST-2013-S0695-L, p. 2695 - 2700
反应条件
oxygen; silver(I) acetate; palladium diacetate; 2,2,2-trimethylacetic acid in N,N-dimethyl-formamide T=140°C; P=760.051 Torr; 20 h; regioselective reaction;
参考文献
Wen, Ping; Li, Yanmei; Zhou, Kang; Ma, Chao; Lan, Xiaobo; Ma, Chaowei; Huang, Guosheng
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 11-12 p. 2135 - 2140
反应条件
1,10-phenanthroline; palladium diacetate; silver carbonate in N,N-dimethyl-formamide T=140°C; 12 h;
参考文献
Ye, Mengchun; Gao, Guo-Lin; Yu, Jin-Quan
Journal of the American Chemical Society, 2011 , vol. 133, # 18 p. 6964 - 6967
反应条件
1: palladium diacetate; pyridine; silver carbonate / 1,4-dioxane / 16 h / 120 °C / |Sealed tube; |Inert atmosphere 2: tetrahydroxydiboron / N,N-dimethyl-formamide; acetonitrile / 0.17 h / 20 °C View Scheme
参考文献
Londregan, Allyn T.; Piotrowski, David W.; Xiao, Jun
Synlett, 2013 , vol. 24, # 20 art. no. ST-2013-S0695-L, p. 2695 - 2700
