2-甲基氨基嘧啶-4-羧醛 二甲基乙缩醛合成路线 （共 4 条）
反应条件
1: methylglyoxylate methanol hemiacetal; N,N-dimethyl-formamide dimethyl acetal T=100°C; 16 h; 2: 1-methylguanidine-hydrochloride With sodium ethanolate in ethanol 24 h; Heating / reflux;
参考文献
PHARMACOPEIA, INC.
Patent: WO2007/104053 A2, 2007 ;
Location in patent: Page/Page column 37-38 ;
WO 2007/104053 A2
反应条件
sodium hydroxide in isopropyl alcohol 20 h; Heating / reflux;
参考文献
Adams, Jerry L.; Boehm, Jeffrey C.; Kassis, Shouki; Gorycki, Peter D.; Webb, Edward F.; Hall, Ralph; Sorenson, Margaret; Lee, John C.; Ayrton, Andrew; Griswold, Don E.; Gallagher, Timothy F.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 22 p. 3111 - 3116
反应条件
1: 18 h / 100 °C 2: aq. NaOH View Scheme
参考文献
Adams, Jerry L.; Boehm, Jeffrey C.; Kassis, Shouki; Gorycki, Peter D.; Webb, Edward F.; Hall, Ralph; Sorenson, Margaret; Lee, John C.; Ayrton, Andrew; Griswold, Don E.; Gallagher, Timothy F.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 22 p. 3111 - 3116
反应条件
sulfuric acid in water T=80°C; 3 h;
参考文献
AVENTIS PHARMA DEUTSCHLAND GMBH
Patent: WO2004/22553 A1, 2004 ;
Location in patent: Page/Page column 19 ;
WO 2004/022553 A1
