dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; sodium carbonate in ethanol T=85°C; Suzuki-Miyaura coupling; 16 h; Inert atmosphere;

in tetrahydrofuran; hexanes T=-40°C; 0.583333 h;

in tetrahydrofuran; hexane T=-40°C; 0.5 h;

1.1: n-butyllithium; tri-isopropoxy-borane / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere 1.2: 4 h / 0 °C 2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; sodium carbonate / ethanol / 16 h / 85 °C / Inert atmosphere View Scheme

1: 2-fluoro-6-phenylpyridine With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.5 h; 2: carbon dioxide in tetrahydrofuran 0.166667 h;