(S)-1-苯基-1,2,3,4-四氢-2-异喹啉甲酸乙酯合成路线 （共 22 条）
反应条件
potassium carbonate in dichloromethane T=20°C;
参考文献
Naito, Ryo; Yonetoku, Yasuhiro; Okamoto, Yoshinori; Toyoshima, Akira; Ikeda, Ken; Takeuchi, Makoto
Journal of Medicinal Chemistry, 2005 , vol. 48, # 21 p. 6597 - 6606
反应条件
sodium carbonate in water; toluene T=14.9 - 34.8°C; 3 h;
参考文献
WO2009/11844 A1, ;
Page/Page column 22-23 ;
反应条件
di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; (R)-3,5-diMe-Synphos; hydrogen in 1,4-dioxane T=40°C; P=22502.3 Torr; 18 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Organic Letters, , vol. 14, # 13 p. 3308 - 3311
反应条件
1: NaBH4 / ethanol / 60 h / 20 °C 2: 100 percent / K2CO3 / CH2Cl2 / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 21 p. 6597 - 6606
反应条件
1: P2O5; POCl3 / xylene / 2.5 h / Heating 2: NaBH4 / ethanol / 60 h / 20 °C 3: 100 percent / K2CO3 / CH2Cl2 / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 21 p. 6597 - 6606
反应条件
1.1: triethylamine / dichloromethane / -10 - 20 °C 2.1: hydrogenchloride; water; phosphoric acid / 95 - 100 °C 2.2: 20 °C / pH 9 - 10 3.1: (2S,3S)-2,3-dihydroxybutanedioic acid / water / 1.5 h / 65 - 95 °C / Resolution of racemate 4.1: acetone / 5 °C / Reflux View Scheme
反应条件
1: (2S,3S)-2,3-dihydroxybutanedioic acid / water / 1.5 h / 65 - 95 °C / Resolution of racemate 2: acetone / 5 °C / Reflux View Scheme
反应条件
1.1: hydrogenchloride; water; phosphoric acid / 95 - 100 °C 1.2: 20 °C / pH 9 - 10 2.1: (2S,3S)-2,3-dihydroxybutanedioic acid / water / 1.5 h / 65 - 95 °C / Resolution of racemate 3.1: acetone / 5 °C / Reflux View Scheme
反应条件
1.1: sodium hydroxide / ethanol / 75 - 80 °C 1.2: Cooling 2.1: triethylamine / dichloromethane / -10 - 20 °C 3.1: hydrogenchloride; water; phosphoric acid / 32 h / 95 - 100 °C 3.2: 20 °C / pH 9 - 10 4.1: (2S,3S)-2,3-dihydroxybutanedioic acid / water / 1.5 h / 65 - 95 °C / Resolution of racemate 5.1: acetone / 5 °C / Reflux View Scheme
反应条件
1.1: hydrogenchloride; water; phosphoric acid / 32 h / 95 - 100 °C 1.2: 20 °C / pH 9 - 10 2.1: (2S,3S)-2,3-dihydroxybutanedioic acid / water / 1.5 h / 65 - 95 °C / Resolution of racemate 3.1: acetone / 5 °C / Reflux View Scheme
