4-乙氧基-3-硝基吡啶合成路线 （共 18 条）
反应条件
sodium hydrogencarbonate in water; ethyl acetate
参考文献
WO2005/46678 A1, ;
Page/Page column 74 ;
WO 2005/046678 A1
反应条件
sodium sulfide T=150°C; 6 h;
参考文献
Morak, Beata; Pluta, Krystian; Suwinska, Kinga; Grymel, Miroslawa; Besnard, Celine; Schiltz, Marc; Kloc, Christian; Siegrist, Theo
Heterocycles, 2005 , vol. 65, # 11 p. 2619 - 2634
反应条件
1: 45 percent / fuming nitric acid, 20percent oleum / 1 h / Heating 2: 94 percent / POCl3, PCl5 / 3 h / Heating 3: 60.4 percent View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 4 p. 467 - 471
反应条件
1: 94 percent / POCl3, PCl5 / 3 h / Heating 2: 60.4 percent View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 4 p. 467 - 471
反应条件
sulfuric acid; sulfur trioxide; nitric acid
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 75, p. 1187,1191
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 75, p. 1187,1191
参考文献
Justus Liebigs Annalen der Chemie, , vol. 529, p. 291
Chemische Berichte, , vol. 60, p. 2108
Chemische Berichte, , vol. 57, p. 1188
参考文献
Chemische Berichte, , vol. 60, p. 2108
反应条件
in ethanol; water T=85°C; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/46678 A1, 2005 ;
Location in patent: Page/Page column 80 ;
WO 2005/046678 A1
反应条件
1: N-ethyl-N,N-diisopropylamine / ethanol / 3 h / 0 °C / |Sealed tube; |Inert atmosphere 2: palladium on activated charcoal; hydrogen / ethanol; water / 4 h / 2585.81 Torr / |Inert atmosphere 3: acetonitrile / 1 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 8, # 6 p. 903 - 908
