2-氟-4-溴苯甲酸甲酯合成路线 （共 12 条）
反应条件
sodium carbonate in DMF (N,N-dimethyl-formamide) T=20°C;
参考文献
NISSAN CHEMICAL INDUSTRIES, LTD.
Patent: WO2004/108683 A1, 2004 ;
Location in patent: Page 557 ;
反应条件
sulfuric acid 20 h; Heating / reflux;
参考文献
GALDERMA RESEARCH and DEVELOPMENT,S.N.C.
Patent: WO2004/46096 A2, 2004 ;
Location in patent: Page 38 ;
反应条件
in tetrahydrofuran; methanol; hexanes T=0 - 20°C; 1 h;
参考文献
EXELIXIS, INC.
Patent: WO2009/55077 A1, 2009 ;
Location in patent: Page/Page column 447 ;
反应条件
chloro-trimethyl-silane in methanol 12 h; Reflux;
参考文献
BAYER HEALTHCARE AG
Patent: US2009/227640 A1, 2009 ;
Location in patent: Page/Page column 42 ;
反应条件
triethylamine T=0 - 20°C; Product distribution / selectivity;
参考文献
US2006/194801 A1, ;
Page/Page column 42 ;
反应条件
1: methanecarbohydroxamic acid With potassium tert-butylate in N,N-dimethyl-formamide 0.5 h; 2: 4-bromo-2-fluorobenzoic acid methyl ester in N,N-dimethyl-formamide T=20°C; 240 h;
参考文献
Miknis, Greg; Lyssikatos, Joseph P.; Laird, Ellen; Tarlton, Eugene; Buckmelter, Alexandre J.; Ren, Li; Rast, Bryson; Schlacter, Stephen T.; Wenglowsky, Steven Mark
Patent: US2007/49603 A1, 2007 ;
Location in patent: Page/Page column 62 ;
US 20070049603 A1
反应条件
zinc cyanide; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=80°C;
参考文献
Penning, Thomas D.; Thomas, Sheela A.; Zhu, Gui-Dong; Gong, Jianchun; Giranda, Vincent L.; Gandhi, Viraj B.
Patent: US2007/112047 A1, 2007 ;
Location in patent: Page/Page column 15-16 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=100°C; 3.5 h;
参考文献
EXELIXIS, INC.
Patent: WO2009/55077 A1, 2009 ;
Location in patent: Page/Page column 447 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 1.5 h; 2: With sodium hydroxide; water in tetrahydrofuran
参考文献
EP1939202 A1, ;
Page/Page column 56-57 ;
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl acetamide T=150°C; P=12929 Torr;
参考文献
Wheeler, Rob C.; Baxter, Emma; Campbell, Ian B.; MacDonald, Simon J. F.
Organic Process Research and Development, 2011 , vol. 15, # 3 p. 565 - 569
