1-(2,4-二羟基苯基)-2-(4-羟基苯基)-乙酮合成路线 (共 22 条)
反应条件
boron trifluoride diethyl etherate T=60 - 70°C; 1 h;
参考文献
Waehaelae, Kristiina; Hase, Tapio A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 12 p. 3005 - 3008
反应条件
boron trifluoride diethyl etherate T=85°C; Acylation; Friedel Crafts; 1.5 h;
参考文献
Balasubramanian, Sreenivasan; Ward, Donald L.; Nair, Muraleedharan G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 2000 , vol. 4, p. 567 - 570
反应条件
pyridine hydrochloride T=220°C; Erwaermen des Reaktionsgemisches mit wss.HCl;
参考文献
Kawase
Bulletin of the Chemical Society of Japan, 1959 , vol. 32, p. 11
反应条件
1: zinc(II) chloride; hydrogenchloride / diethyl ether / 20 °C 2: hydrogenchloride; water / |Reflux View Scheme
参考文献
Mascayano, Carolina; Espinosa, Victoria; Sepulveda-Boza, Silvia; Hoobler, Eric K.; Perry, Steve
Chemical Biology and Drug Design, 2013 , vol. 82, # 3 p. 317 - 325
反应条件
1: zinc(II) chloride; hydrogenchloride / diethyl ether / 20 °C 2: hydrogenchloride; water / |Reflux View Scheme
参考文献
Mascayano, Carolina; Espinosa, Victoria; Sepulveda-Boza, Silvia; Hoobler, Eric K.; Perry, Steve
Chemical Biology and Drug Design, 2013 , vol. 82, # 3 p. 317 - 325
反应条件
hydrogenchloride; diethyl ether; zinc(II) chloride Erhitzen des Reaktionsprodukts mit Wasser;
参考文献
Walz
Justus Liebigs Annalen der Chemie, 1931 , vol. 489, p. 118,127, 140
反应条件
pyridin-2-yl hydrobromide 0.0166667 h; Heating;
参考文献
Jain, Amolak C.; Nayyar, Naresh K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 136 - 139
反应条件
1: With triethylamine 1 h; Heating / reflux; 2: With hydrogenchloride in water T=20°C; pH=5; 2 h;
参考文献
NOVOGEN RESEARCH PTY LTD
Patent: WO2009/3229 A1, 2009 ;
Location in patent: Page/Page column 73 ;
WO 2009/003229 A1
反应条件
1: 29 percent / 50percent aq. KOH / acetone; dimethylformamide / 4 h / Ambient temperature 2: BF3*Et2O, PCl5 / 70 °C 3: 1 N aq. NaOH / methanol / 0.25 h View Scheme
参考文献
Farkas; Varady
Chemische Berichte, 1959 , vol. 92, p. 819
反应条件
toluene-4-sulfonic acid in ethyl acetate T=25°C; 16 h;
参考文献
Endorecherche, Inc.
Patent: US6670346 B1, 2003 ;
Location in patent: Page column 31; 34 ;