3-甲氧基-10H-吩噻嗪合成路线 （共 20 条）
反应条件
(i) nBuLi, Et2O, (ii) /BRN= 1968816/; Multistep reaction;
参考文献
Jackson; Shirley
Journal of medicinal chemistry, 1968 , vol. 11, # 3 p. 622 - 623
反应条件
pyridine hydrochloride T=200°C;
参考文献
Kadaba; Massie
Journal of Organic Chemistry, 1959 , vol. 24, p. 986
反应条件
3,3,4,4-tetramethyl-1,2-dioxetane in acetonitrile T=15°C; 10 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Adam, Waldemar; Hueckmann, Sabine; Vargas, Franklin
Tetrahedron Letters, 1989 , vol. 30, # 46 p. 6315 - 6318
反应条件
in acetonitrile T=15°C; 10 h; reaction of other phenothiazines; MechanismProduct distribution;
参考文献
Adam, Waldemar; Hueckmann, Sabine; Vargas, Franklin
Tetrahedron Letters, 1989 , vol. 30, # 46 p. 6315 - 6318
反应条件
phenylmethylsulfonylbenzene; oxygen; potassium iodide in chlorobenzene
T=140°C; 24 h;
参考文献
Liao, Yunfeng; Jiang, Pengcheng; Chen, Shanping; Xiao, Fuhong; Deng, Guo-Jun
RSC Advances, 2013 , vol. 3, # 40 p. 18605 - 18608
参考文献
Gilman; Shirley
Journal of the American Chemical Society, 1944 , vol. 66, p. 888,891
Full Text Show Details
Baltzly et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 2673,2677
反应条件
sodium hydroxide in water
T=20°C; Methylation;
参考文献
Yamamura, Tatsuo; Suzuki, Kyouichi; Yamaguchi, Tatsuya; Nishiyama, Tomihiro
Bulletin of the Chemical Society of Japan, 1997 , vol. 70, # 2 p. 413 - 419
反应条件
copper(l) iodide; potassium carbonate in dimethyl sulfoxide
T=120°C; 48 h; Inert atmosphere; regioselective reaction;
参考文献
Dai, Chuan; Sun, Xiaofei; Tu, Xingzhao; Wu, Li; Zhan, Dan; Zeng, Qingle
Chemical Communications, 2012 , vol. 48, # 43 p. 5367 - 5369
反应条件
copper(l) iodide; 1,10-phenanthroline; caesium carbonate in dimethyl sulfoxide
T=170°C; 34 h; Inert atmosphere;
参考文献
Beresneva; Abele
Chemistry of Heterocyclic Compounds, 2012 , vol. 48, # 9 p. 1420 - 1422
Khim. Geterotsikl. Soedin., 2012 , vol. 48, # 9 p. 1521 - 1524,3
反应条件
1: K3PO4; X-phos / Pd2dba3 / toluene / 20 h / Heating
2: sulfur; I2 / H2O / 0.33 h / 190 °C / microwave irradiation
View Scheme
参考文献
Madrid, Peter B.; Polgar, Willma E.; Toll, Lawrence; Tanga, Mary J.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 11 p. 3014 - 3017
