4,4'-二氯-2,2'-联吡啶合成路线 （共 20 条）
反应条件
trichlorophosphate in chloroform 19 h; Inert atmosphereRefluxSchlenk technique;
参考文献
Ladouceur, Sebastien; Swanick, Kalen N.; Gallagher-Duval, Shawn; Ding, Zhifeng; Zysman-Colman, Eli
European Journal of Inorganic Chemistry, 2013 , # 30 p. 5329 - 5343
反应条件
copper(l) iodide; tetrabutyl ammonium fluoride; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran; N,N-dimethyl-formamide T=20°C; Hiyama cross-coupling; 12 h;
参考文献
Pierrat, Philippe; Gros, Philippe; Fort, Yves
Organic Letters, 2005 , vol. 7, # 4 p. 697 - 700
反应条件
hexamethyl-distannane; tetrakis(triphenylphosphine) palladium(0) in xylene T=130°C; Stille coupling; 20 h;
参考文献
Garcia-Lago, Ramon; Alonso-Gomez, Jose-Lorenzo; Sicre, Cristina; Cid, Maria-Magdalena
Heterocycles, 2008 , vol. 75, # 1 p. 57 - 64
反应条件
tetrabutyl ammonium fluoride; silver(l) oxide in N,N-dimethyl-formamide T=20°C; 12 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 6 p. 1768 - 1773
反应条件
1: With copper(l) iodide; tetrabutyl ammonium fluoride in tetrahydrofuran; N,N-dimethyl-formamide T=20°C; 0.0833333 h; Inert atmosphere; 2: With oxygen in tetrahydrofuran; N,N-dimethyl-formamide T=20°C; 12 h;
参考文献
Louerat, Frederic; Gros, Philippe C.
Tetrahedron Letters, 2010 , vol. 51, # 27 p. 3558 - 3560
反应条件
copper(l) iodide; tetrabutyl ammonium fluoride; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran; N,N-dimethyl-formamide T=20°C; Hiyama cross-coupling; 12 h; Title compound not separated from byproducts;
参考文献
Pierrat, Philippe; Gros, Philippe; Fort, Yves
Organic Letters, 2005 , vol. 7, # 4 p. 697 - 700
反应条件
phosphorus trichoride T=60°C;
参考文献
Nippon Kagaku Zasshi, , vol. 77, p. 682,685
Chem.Abstr., , p. 9100
Yakugaku Zasshi, , vol. 75, p. 733,735
Chem.Abstr., , p. 3436
反应条件
1: 94 percent / aq. H2O2; AcOH / 13 h / 70 - 80 °C 2: 52 percent / HNO3; H2SO4/SO3 / 8 h / 100 °C 3: 80 percent / AcCl; AcOH / 4 h / 100 °C 4: 86 percent / PCl3 / acetonitrile / 6 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 71, # 1 p. 315 - 319
反应条件
1: 52 percent / HNO3; H2SO4/SO3 / 8 h / 100 °C 2: 80 percent / AcCl; AcOH / 4 h / 100 °C 3: 86 percent / PCl3 / acetonitrile / 6 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 71, # 1 p. 315 - 319
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; triphenylphosphine in tetrahydrofuran; N,N-dimethyl-formamide T=20°C; 12 h; Inert atmosphere;
参考文献
Tetrahedron Letters, , vol. 51, # 27 p. 3558 - 3560
