3-氯-5,5-二甲基-2-环己烯-1-酮合成路线 （共 38 条）
反应条件
hydrogenchloride in ethanol
electrolysis; Yield given;
参考文献
Matschiner, H.; Voigtlaender, R.; Schick, H.; Lund, H.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1980 , vol. 34, # 2 p. 136 - 138
参考文献
Crossley; Renouf
Journal of the Chemical Society, 1907 , vol. 91, p. 74
反应条件
Fe(S-2-naphthyl)2 in tetrahydrofuran
T=0°C; 1 h; Inert atmosphere;
参考文献
Cahiez, Gerard; Gager, Olivier; Buendia, Julien; Patinote, Cindy
Chemistry - A European Journal, 2012 , vol. 18, # 19 p. 5860 - 5863
反应条件
2: 2.) TsOH / 1.) THF, 2.) dioxane, H2O, room temp., 48 h
View Scheme
参考文献
Comasseto, Joao V.; Lo, Wai L.; Petragnani, Nicola
Tetrahedron, 1997 , vol. 53, # 22 p. 7445 - 7460
反应条件
1: H2 / 5percent palladium on charcoal
2: 1.) PCl5, 2.) NaOEt / 2.) reflux, 19 h
3: 69 percent / Na
4: 10 percent / AlCl3 / CH2Cl2 / 6.25 h / 0 °C
View Scheme
参考文献
Fleming, Ian; Pearce, Andrew
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2485 - 2489
反应条件
in ethanol
0.333333 h; Heating / reflux;
参考文献
UCB PHARMA S.A.
Patent: WO2009/71890 A1, 2009 ;
Location in patent: Page/Page column 100 ;
WO 2009/071890 A1
参考文献
Crossley; Le Sueur
Journal of the Chemical Society, 1903 , vol. 83, p. 116,128
反应条件
CuSPh in tetrahydrofuran
1.) -78 deg C to -15 deg C, 20 min, -15 deg C, 10 min, 2.) -15 deg C, 1 h;
参考文献
Wender, Paul A.; White, Alan W.
Journal of the American Chemical Society, 1988 , vol. 110, # 7 p. 2218 - 2223
