4-(1-己炔-1-基)-苯甲腈合成路线 （共 9 条）
反应条件
C34H40Br2N3Pd; potassium carbonate in dimethyl sulfoxide T=100°C; Sonogashira coupling; 1 h;
参考文献
Yang, Longguang; Guan, Pei; He, Pan; Chen, Qian; Cao, Changsheng; Peng, Yu; Shi, Zhan; Pang, Guangsheng; Shi, Yanhui
Dalton Transactions, 2012 , vol. 41, # 16 p. 5020 - 5025
反应条件
pyrrolidine; air; palladium dichloride in water T=25°C; Sonogashira reaction; 24 h;
参考文献
Liang, Bo; Dai, Mingji; Chen, Jiahua; Yang, Zhen
Journal of Organic Chemistry, 2005 , vol. 70, # 1 p. 391 - 393
反应条件
N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in water; isopropyl alcohol T=100°C; 0.25 h; Microwave irradiation;
参考文献
Kabalka, George W.; Naravane, Abhijit; Zhao, Li Li
Tetrahedron Letters, 2007 , vol. 48, # 40 p. 7091 - 7093
反应条件
caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in tetrahydrofuran; water Suzuki-Miyaura cross-coupling; 12 h; Heating;
参考文献
Molander, Gary A.; Katona, Bryson W.; Machrouhi, Fouzia
Journal of Organic Chemistry, 2002 , vol. 67, # 24 p. 8416 - 8423
反应条件
copper(l) iodide; diisopropylamine; triphenylphosphine; palladium on activated charcoal in N,N-dimethyl acetamide; water T=80°C; Sonogashira coupling; 48 h;
参考文献
Novak, Zoltan; Szabo, Andras; Repasi, Jozsef; Kotschy, Andras
Journal of Organic Chemistry, 2003 , vol. 68, # 8 p. 3327 - 3329
反应条件
potassium phosphate; CM-phos; palladium diacetate in tert-butyl alcohol T=20 - 110°C; Sonogashira coupling; 18 h; Inert atmosphere;
参考文献
Choy, Pui Ying; Chow, Wing Kin; So, Chau Ming; Lau, Chak Po; Kwong, Fuk Yee
Chemistry - A European Journal, 2010 , vol. 16, # 33 p. 9982 - 9985
反应条件
1: 4-cyanophenylacetylene With bis[2-(N,N-dimethylamino)ethyl] ether; ethylmagnesium bromide in tetrahydrofuran T=20°C; 2.25 h; 2: 1-iodo-butane With ((Me)N2N)Ni-Cl in tetrahydrofuran T=20°C; Kumada coupling reaction; 6 h;
参考文献
Vechorkin, Oleg; Godinat, Aurelien; Scopelliti, Rosario; Hu, Xile
Angewandte Chemie - International Edition, 2011 , vol. 50, # 49 p. 11777 - 11781
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C 1.2: B(OMe)3 / tetrahydrofuran; hexane / 2 h / -78 - -20 °C 1.3: 78 percent / aq. KHF2 / tetrahydrofuran; hexane / 2 h / -20 - 20 °C 2.1: 99 percent / Cs2CO3 / PdCl2(dppf)*CH2Cl2 / tetrahydrofuran; H2O / 12 h / Heating View Scheme
参考文献
Molander, Gary A.; Katona, Bryson W.; Machrouhi, Fouzia
Journal of Organic Chemistry, 2002 , vol. 67, # 24 p. 8416 - 8423
反应条件
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C 2.1: bis[2-(N,N-dimethylamino)ethyl] ether; ethylmagnesium bromide / tetrahydrofuran / 2.25 h / 20 °C 2.2: 6 h / 20 °C View Scheme
参考文献
Vechorkin, Oleg; Godinat, Aurelien; Scopelliti, Rosario; Hu, Xile
Angewandte Chemie - International Edition, 2011 , vol. 50, # 49 p. 11777 - 11781
