(E)-3-环己基-2-丙烯酸乙酯合成路线 （共 42 条）
反应条件
lithium hydroxide in tetrahydrofuran; water T=60°C; 12 h;
参考文献
Alhamadsheh, Mamoun M.; Palaniappan, Nadaraj; DasChouduri, Suparna; Reynolds, Kevin A.
Journal of the American Chemical Society, 2007 , vol. 129, # 7 p. 1910 - 1911
反应条件
diisobutylaluminium hydride in hexane; dichloromethane T=-78°C; 1 h;
参考文献
Barrett, Anthony G. M.; Doubleday, Wendel W.; Tustin, Gary J.
Tetrahedron, 1996 , vol. 52, # 48 p. 15325 - 15338
反应条件
1: DIBAL-H / CH2Cl2 / 2 h / 0 °C 2: DMAP, pyridine / CH2Cl2 / 3.5 h / Ambient temperature View Scheme
参考文献
Persson, Eva S. M.; Baeckvall, Jan-E.
Acta Chemica Scandinavica, 1995 , vol. 49, # 12 p. 899 - 906
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride in ethylene glycol dimethyl ether
T=0 - 20°C;
2: cyclohexanecarbaldehyde in ethylene glycol dimethyl ether
4 h;
参考文献
Alhamadsheh, Mamoun M.; Palaniappan, Nadaraj; DasChouduri, Suparna; Reynolds, Kevin A.
Journal of the American Chemical Society, 2007 , vol. 129, # 7 p. 1910 - 1911
反应条件
triphenylphosphine; nanocrystalline aerogel prepared MgO in N,N-dimethyl-formamide
T=20°C; Wittig reaction; 10 h;
参考文献
Choudary, Boyapati M.; Mahendar, Koosam; Kantam, M. Lakshmi; Ranganath, Kalluri V. S.; Athar, Taimur
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 14 p. 1977 - 1985
反应条件
Fe(TCP)Cl; polyethylene supported arsine; polymethylhydrosiloxane in toluene
T=110°C; Wittig type reaction; 12 h; Inert atmosphere; optical yield given as percent destereoselective reaction;
参考文献
Wang, Peng; Liu, Chun-Rong; Sun, Xiu-Li; Chen, Shuai-Shuai; Li, Jun-Fang; Xie, Zuowei; Tang, Yong
Chemical Communications, 2012 , vol. 48, # 2 p. 290 - 292
反应条件
triphenylphosphine in toluene
T=80°C; 7 h; Inert atmosphere; optical yield given as percent destereoselective reaction;
参考文献
Chinnusamy, Tamilselvi; Rodionov, Valentin; Kuehn, Fritz E.; Reiser, Oliver
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 9 p. 1827 - 1831
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride in tetrahydrofuran
T=-78 - 0°C; Wittig-Horner-Emmons; 1 h;
2: cyclohexanecarbaldehyde in tetrahydrofuran
T=-68 - 20°C; 19.5 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/63179 A1, 2004 ;
Location in patent: Page 106 ;
WO 2004/063179 A1
反应条件
potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene
Horner-Wadsworth-Emmons reaction; 4 h; Inert atmosphereneat (no solvent); optical yield given as percent destereoselective reaction;
参考文献
Ando, Kaori; Yamada, Kyohei
Green Chemistry, 2011 , vol. 13, # 5 p. 1143 - 1146
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride in tetrahydrofuran
T=0 - 20°C;
参考文献
Park, Jin Kyoon; Lackey, Hershel H.; Rexford, Matthew D.; Kovnir, Kirill; Shatruk, Michael; McQuade, D. Tyler
Organic Letters, 2010 , vol. 12, # 21 p. 5008 - 5011
