2-[4-[(2,4-二氧代-5-噻唑啉)甲基]苯氧基]乙酸乙酯合成路线 （共 7 条）
反应条件
hydrogenchloride; thiourea in ethanol
参考文献
Sankyo Company, Limited
Patent: US5624935 A1, 1997 ;
反应条件
1.1: 75 percent / K2CO3 / dimethylformamide / 48 h / 20 °C 2.1: 98 percent / H2 / 10percent Pd/C / methanol / 6 h / 20 °C 3.1: aq. NaNO2; aq. HBr / methanol; acetone / 0.5 h 3.2: CuBr / methanol; acetone / 20 °C 4.1: 2.5 h / Heating 4.2: aq. HCl / 5 h / Heating View Scheme
参考文献
Oguchi; Wada; Honma; Tanaka; Kaneko; Sakakibara; Ohsumi; Serizawa; Fujiwara; Horikoshi; Fujita
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3052 - 3066
反应条件
1.1: 98 percent / H2 / 10percent Pd/C / methanol / 6 h / 20 °C 2.1: aq. NaNO2; aq. HBr / methanol; acetone / 0.5 h 2.2: CuBr / methanol; acetone / 20 °C 3.1: 2.5 h / Heating 3.2: aq. HCl / 5 h / Heating View Scheme
参考文献
Oguchi; Wada; Honma; Tanaka; Kaneko; Sakakibara; Ohsumi; Serizawa; Fujiwara; Horikoshi; Fujita
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3052 - 3066
参考文献
Dr. Reddy's Research Foundation; Reddy-Cheminor Inc.
Patent: US6310069 B1, 2001 ;
反应条件
1.1: aq. NaNO2; aq. HBr / methanol; acetone / 0.5 h 1.2: CuBr / methanol; acetone / 20 °C 2.1: 2.5 h / Heating 2.2: aq. HCl / 5 h / Heating View Scheme
参考文献
Oguchi; Wada; Honma; Tanaka; Kaneko; Sakakibara; Ohsumi; Serizawa; Fujiwara; Horikoshi; Fujita
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3052 - 3066
反应条件
1: thiourea; methyl 4-(2-bromo-2-n-butoxycarbonylethyl)phenoxyacetate Cyclization; 2.5 h; Heating; 2: ethanol With hydrogenchloride Ethanolysis; 5 h; Heating; Further stages.;
参考文献
Oguchi; Wada; Honma; Tanaka; Kaneko; Sakakibara; Ohsumi; Serizawa; Fujiwara; Horikoshi; Fujita
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3052 - 3066
反应条件
sodium carbonate in methanol; water
参考文献
Dr. Reddy's Research Foundation; Reddy-Cheminor Inc.
Patent: US6310069 B1, 2001 ;
