3-氨基-6-溴吡嗪-2-甲腈合成路线 （共 9 条）
反应条件
bromine; acetic acid T=60°C; 4 h;
参考文献
Taylor, Edward C.; Ray, Partha S.
Journal of Organic Chemistry, 1987 , vol. 52, # 18 p. 3997 - 4000
反应条件
1: sodium cyanide; copper (I) cyanide in N,N-dimethyl-formamide T=125°C; 2: 3,5-dibromopyrazine-2-ylamine in N,N-dimethyl-formamide T=125°C; 5 h;
参考文献
Folmer, Brigitte Johanna Bernita; Man, de Adrianus Petrus Antonius; Gernette, Elisabeth Sophia; Corte Real Goncalves Azevedo, Rita; Ibrahim, Hemen
Patent: US2013/79341 A1, 2013 ;
Location in patent: Paragraph 0119 ;
反应条件
copper(l) iodide; 18-crown-6 ether; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide 1 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 24, p. 1371 - 1372
反应条件
in N,N-dimethyl-formamide T=120 - 130°C; 2.5 h;
参考文献
Synthesis, , # 8 p. 659 - 660
反应条件
copper(l) iodide; triethylamine; triphenylphosphine; palladium dichloride in acetonitrile 18 h; Ambient temperature;
参考文献
Taylor, Edward C.; Ray, Partha S.
Journal of Organic Chemistry, 1987 , vol. 52, # 18 p. 3997 - 4000
反应条件
copper(l) iodide; triethylamine; triphenylphosphine; palladium dichloride in acetonitrile 18 h; Ambient temperature;
参考文献
Taylor, Edward C.; Ray, Partha S.
Journal of Organic Chemistry, 1987 , vol. 52, # 18 p. 3997 - 4000
反应条件
1: With copper dichloride in acetonitrile T=60°C; 0.166667 h; 2: With tert.-butylnitrite in acetonitrile T=60°C; 16 h;
参考文献
US2010/298334 A1, ;
Page/Page column 105 ;
US 20100298334 A1
反应条件
tert.-butylnitrite; copper(ll) bromide in acetonitrile
T=50°C; Sandmeyer Reaction; 4 h;
参考文献
Folmer, Brigitte Johanna Bernita; Man, de Adrianus Petrus Antonius; Gernette, Elisabeth Sophia; Corte Real Goncalves Azevedo, Rita; Ibrahim, Hemen
Patent: US2013/79341 A1, 2013 ;
Location in patent: Paragraph 0120 ;
反应条件
1.1: 40 percent / DMAP / 1,2-dichloro-ethane / 22 h / Heating
2.1: NaH / tetrahydrofuran / 0.33 h / 20 °C
2.2: tetrahydrofuran / 1 h / 20 °C
3.1: HCl; H2O / acetonitrile / 5 h / Heating
4.1: 79 percent
View Scheme
参考文献
Sato, Nobuhiro; Fukuya, Shunsuke
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 2000 , # 1 p. 89 - 96
