(S)-(+)-扁桃酸合成路线 （共 229 条）
反应条件
nachfolgend Verduennen der Loesung; higher-melting form;
参考文献
Journal of the Chemical Society, , p. 698
参考文献
Finska Kemistsamf. Medd., , vol. 49, p. 42. 45, 46
反应条件
1: thionyl chloride; N,N-dimethyl-formamide / tetrahydrofuran 2: water View Scheme
参考文献
Marzorati, Liliana; Fejfar, Jose L.; Tormena, Claudio F.; Vitta, Claudio Di
Tetrahedron Asymmetry, 2012 , vol. 23, # 10 p. 748 - 753
反应条件
1: PBr5 2: water View Scheme
参考文献
Walden
Chemische Berichte, 1895 , vol. 28, p. 1295,1296
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1898 , vol. 30, p. 535,538
反应条件
1.1: 60 percent / p-TsOH; H2SO4 / pentane / 24 h / Heating 2.1: lithium diisopropylamine / hexane; diethyl ether / 0.5 h / -78 °C 2.2: hexane; diethyl ether / 2 h / -78 °C 3.1: aq. KOH / methanol / 3 h / Heating View Scheme
参考文献
Frater, Gy.; Mueller, U.; Guenther, W.
Tetrahedron Letters, 1981 , vol. 22, # 42 p. 4221 - 4224
反应条件
1: 72 percent / LiAlH4 / diethyl ether / 2 h / Heating 2: 88 percent / Bu2SnO; Et3N / CH2Cl2 / 3 h / 20 °C View Scheme
参考文献
Mizuno, Masashi; Kanai, Motomu; Iida, Akira; Tomioka, Kiyoshi
Tetrahedron, 1997 , vol. 53, # 31 p. 10699 - 10708
反应条件
1-amino-1-phenylethane in hexan-1-ol T=130°C; Racemization; Kinetics; Further Variations:ReagentsSolventsTemperatures;
参考文献
Hollemann
Recueil des Travaux Chimiques des Pays-Bas, 1898 , vol. 17, p. 324
反应条件
1: conc. H2SO4 / 5 h / Heating 2: 1.) Mg, I2 / 1.) THF, reflux, 3 h; 2.) THF, reflux, 3-5 h 3: pyridine / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Devant, Ralf; Mahler, Ulrike; Braun, Manfred
Chemische Berichte, 1988 , vol. 121, p. 397 - 406
反应条件
in acetonitrile 16 h;
参考文献
ABBOTT LABORATORIES
Patent: WO2006/34234 A1, 2006 ;
Location in patent: Page/Page column 17-18 ;
反应条件
1: 80 percent / BH3*THF / tetrahydrofuran / 5 h / Ambient temperature 2: 79 percent / pyridine / 4 h / -10 °C 3: 68 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature View Scheme
参考文献
Ley, Steven V.; Parra, Margarita; Redgrave, Alison J.; Sternfeld, Francine
Tetrahedron, 1990 , vol. 46, # 13/14 p. 4994 - 5026
