(1S,3S)-1-(1,3-苯并二氧戊环-5-基)-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚-3-羧酸甲酯合成路线

参考文献

LEK Pharmaceuticals d.d.
Patent: EP2107059 A1, 2009 ;
Location in patent: Page/Page column 9 ;

171596-44-4(1R,3S)-1,2,3,4-四氢-1-(3,4-亚甲二氧基苯基)-9H-吡啶并[3,4-B]吲哚-3-羧酸甲酯盐酸盐他达那非杂质+

171596-43-3(1S,3S)-1-(1,3-苯并二氧戊环-5-基)-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚-3-羧酸甲酯

参考文献

Daugan, Alain; Grondin, Pascal; Ruault, Cecile; Le Monnier de Gouville, Anne-Charlotte; Coste, Herve; Linget, Jean Michel; Kirilovsky, Jorge; Hyafil, Francois; Labaudinieret, Richard
Journal of Medicinal Chemistry, 2003 , vol. 46, # 21 p. 4533 - 4542

120-57-0胡椒醛+

7524-52-9L-色氨酸甲酯盐酸盐

171596-43-3(1S,3S)-1-(1,3-苯并二氧戊环-5-基)-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚-3-羧酸甲酯

参考文献

Xiao, Sen; Shi, Xiao-Xin; Xing, Jing; Yan, Jing-Jing; Liu, Shi-Ling; Lu, Wei-Dong
Tetrahedron Asymmetry, 2009 , vol. 20, # 18 p. 2090 - 2096

171596-43-3(1S,3S)-1-(1,3-苯并二氧戊环-5-基)-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚-3-羧酸甲酯

629652-72-8ENT-他达拉非

参考文献

Daugan, Alain; Grondin, Pascal; Ruault, Cecile; Le Monnier de Gouville, Anne-Charlotte; Coste, Herve; Linget, Jean Michel; Kirilovsky, Jorge; Hyafil, Francois; Labaudinieret, Richard
Journal of Medicinal Chemistry, 2003 , vol. 46, # 21 p. 4533 - 4542

171596-43-3(1S,3S)-1-(1,3-苯并二氧戊环-5-基)-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚-3-羧酸甲酯

171596-42-2(1S,3R)-甲基-1,2,3,4-四氢-1-(3,4-亚甲二氧基苯基)-9H-吡啶并[3,4-b]吲哚-3-羧酸酯

参考文献

Dong, Jing; Meng, Tian-Zhuo; Shi, Xiao-Xin; Zou, Wen-Hui; Lu, Xia
Tetrahedron Asymmetry, 2013 , vol. 24, # 15-16 p. 883 - 893