(3-苄氧基-4-甲氧基苯基)-乙腈合成路线 （共 19 条）
反应条件
potassium tert-butylate in tetrahydrofuran; methanol; water
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: With potassium tert-butylate in tetrahydrofuran T=-78°C; 1.75 h; 2: With methanol in tetrahydrofuran 0.5 h; Heating / reflux;
参考文献
Hadida Ruah, Sara S.; Grootenhuis, Peter D.J.; Van Goor, Frederick; Zhou, Jinglan; Bear, Brian; Miller, Mark T.; McCartney, Jason; Numa, Mehdi Michel Jamel
Patent: US2007/244159 A1, 2007 ;
Location in patent: Page/Page column 89; 90 ;
反应条件
urea; potassium iodide in acetone 6 h; Heating;
参考文献
Bhandari, Prabha; Crombie, Leslie; Daniels, Peter; Holden, Ian; Bruggen, Nicholas Van; Whiting, Donald A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 7 p. 839 - 850
反应条件
1: 85 percent / SOCl2 / dioxane / 1 h / 20 °C 2: 70 percent / acetonitrile / 24 h / 20 °C View Scheme
参考文献
Nakazato, Atsuro; Ohta, Kohmei; Sekiguchi, Yoshinori; Okuyama, Shigeru; Chaki, Shigeyuki; Kawashima, Yutaka; Hatayama, Katsuo
Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 1076 - 1087
反应条件
1: 98 percent / K2CO3 / methanol / 5 h / Heating 2: 90 percent / NaBH4 / methanol / 1 h / 20 °C 3: 85 percent / SOCl2 / dioxane / 1 h / 20 °C 4: 70 percent / acetonitrile / 24 h / 20 °C View Scheme
参考文献
Nakazato, Atsuro; Ohta, Kohmei; Sekiguchi, Yoshinori; Okuyama, Shigeru; Chaki, Shigeyuki; Kawashima, Yutaka; Hatayama, Katsuo
Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 1076 - 1087
反应条件
in acetonitrile T=20°C; 24 h;
参考文献
Lisowski, Vincent; Enguehard, Cecile; Lancelot, Jean-Charles; Caignard, Daniel-Henri; Lambel, Stephanie; Leonce, Stephane; Pierre, Alain; Atassi, Ghanem; Renard, Pierre; Rault, Sylvain
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 16 p. 2205 - 2208
反应条件
1: K2CO3 / dimethylformamide / 5 h / 40 - 50 °C 2: NaBH4, 0.5N aq. NaOH / tetrahydrofuran / 2.5 h / Ambient temperature 3: SOCl2 / tetrahydrofuran; dimethylformamide / 1 h / Ambient temperature 4: 18-crown-6 / acetonitrile / 7 h / Heating View Scheme
参考文献
Bhandari, Prabha; Crombie, Leslie; Daniels, Peter; Holden, Ian; Bruggen, Nicholas Van; Whiting, Donald A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 7 p. 839 - 850
反应条件
sodium cyanide; sodium iodide in butanone
参考文献
Kupchan,S.M.; Yoshitake,A.
Journal of Organic Chemistry, 1969 , vol. 34, # 4 p. 1062 - 1065
反应条件
18-crown-6 ether in acetonitrile 7 h; Heating;
参考文献
Nakazato, Atsuro; Ohta, Kohmei; Sekiguchi, Yoshinori; Okuyama, Shigeru; Chaki, Shigeyuki; Kawashima, Yutaka; Hatayama, Katsuo
Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 1076 - 1087
反应条件
in N,N-dimethyl-formamide
参考文献
Lee, Jeewoo; Kang, Sang Uk; Kim, Su Yeon; Kim, Sung Eun; Jo, Yeong Joon; Kim, Sunghoon
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 8 p. 965 - 968
