(4-噻吩-2-苯基)甲醇合成路线 （共 55 条）
反应条件
potassium carbonate; mono(bis(di-tert-butyl(4-(dimethylamino)phenyl)phosphonio)palladium(II))dichloride in water; toluene Suzuki-Miyaura cross-coupling; 12 h; Heating;
参考文献
Organic Letters, , vol. 8, # 9 p. 1787 - 1789
反应条件
potassium carbonate; [PS-PEG-adppp-Pd(η3-C3H5)]Cl in water T=50°C; Suzuki-Miyaura coupling; 12 h;
参考文献
Organic Letters, , vol. 4, # 17 p. 2997 - 3000
反应条件
1: thiophene With ethyl magnesium chloride; N,N-dicyclohexylamine in tetrahydrofuran T=60°C; 24 h; 2: para-bromotoluene With PEPPSI™.IPr in tetrahydrofuran T=20°C; 24 h;
参考文献
Tetrahedron Letters, , vol. 53, # 9 p. 1173 - 1176
反应条件
potassium carbonate; [PS-PEG-adppp-Pd(η3-C3H5)]Cl in water T=50°C; Suzuki-Miyaura coupling; 12 h;
参考文献
Organic Letters, , vol. 4, # 17 p. 2997 - 3000
反应条件
2,2'-bis(di-p-tolyl-phosphino)-1,1'-binaphthyl; copper(I) oxide; 1,10-phenanthroline; palladium (II) 2,4-pentanedionate in 1-methyl-pyrrolidin-2-one T=50 - 190°C; P=3375.34 Torr; Inert atmosphereMicrowave irradiation;
参考文献
Chemistry - A European Journal, , vol. 15, # 37 p. 9336 - 9349
反应条件
tri-tert-butyl phosphine; boron trifluoride diethyl etherate; tris(dibenzylideneacetone)dipalladium (0) in ethylene glycol dimethyl ether; hexane T=20°C; 1 h;
参考文献
Organic Letters, , vol. 6, # 4 p. 617 - 619
反应条件
quinoline; CuF2; palladium (II) bromide; biphenyl-2-yl-di-tert-butyl-phosphane in 1-methyl-pyrrolidin-2-one T=170°C; 24 h;
参考文献
Angewandte Chemie - International Edition, , vol. 47, # 37 p. 7103 - 7106
反应条件
cesium fluoride in ethanol; water T=50°C; Stille coupling; 8 h; Inert atmosphere;
参考文献
Green Chemistry, , vol. 12, # 11 p. 2024 - 2029
反应条件
(IPr)Ni(π-allyl)Cl in tetrahydrofuran T=20°C; Kumada Cross-Coupling; 12 h; Inert atmosphere;
参考文献
Organic Letters, , vol. 14, # 17 p. 4318 - 4321
反应条件
1: thiophene-2-carboxylic acid With potassium carbonate in various solvent(s) T=120°C; 0.5 h; 2: para-bromotoluene With 1,10-phenanthroline; copper(I) bromide in various solvent(s) T=170°C; 24 h; Further stages.;
参考文献
Journal of the American Chemical Society, , vol. 129, # 15 p. 4824 - 4833
