N-苄氧羰基-D-缬氨酸合成路线 （共 23 条）
反应条件
sodium hydrogencarbonate Acylation;
参考文献
Liang; Richard; Portonovo; Joullie
Journal of the American Chemical Society, 2001 , vol. 123, # 19 p. 4469 - 4474
反应条件
hydrogen; triethylamine; aka TetraMe-BITIOP; [Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2 in ethanol; 1,2-dichloro-ethane T=25°C; P=4654.33 Torr; 24 h;
参考文献
Shultz, C. Scott; Dreher, Spencer D.; Ikemoto, Norihiro; Williams, J. Michael; Grabowski, Edward J. J.; Krska, Shane W.; Sun, Yongkui; Dormer, Peter G.; DiMichele, Lisa
Organic Letters, 2005 , vol. 7, # 16 p. 3405 - 3408
反应条件
lithium hydroxide in tetrahydrofuran T=20°C; 4 h;
参考文献
Miyabe, Hideto; Nishimura, Azusa; Ueda, Masafumi; Naito, Takeaki
Chemical Communications, 2002 , # 14 p. 1454 - 1455
反应条件
industrial papain T=50°C; 4 h; pH 4,5 (citrate buffer, cystein*HCl);
参考文献
European Journal of Medicinal Chemistry, , vol. 22, p. 347 - 358
反应条件
1: 3.8 g / methanesulfonic acid / toluene / 2 h / Heating 2: 94 percent / H2; (-)-[4'-(PPh2)-2,2',5,5'-Me4-3,3'-bithien-4-yl]PPh2; Et3N / [(p-cymene)RuCl2]2 / ethanol; 1,2-dichloro-ethane / 24 h / 25 °C / 4654.33 Torr View Scheme
参考文献
Organic Letters, , vol. 7, # 16 p. 3405 - 3408
反应条件
1: LiOH*H2O / tetrahydrofuran / 20 °C 2: 3.8 g / methanesulfonic acid / toluene / 2 h / Heating 3: 94 percent / H2; (-)-[4'-(PPh2)-2,2',5,5'-Me4-3,3'-bithien-4-yl]PPh2; Et3N / [(p-cymene)RuCl2]2 / ethanol; 1,2-dichloro-ethane / 24 h / 25 °C / 4654.33 Torr View Scheme
参考文献
Organic Letters, , vol. 7, # 16 p. 3405 - 3408
反应条件
1: 77 percent / H2 / Pd(OH)2 / methanol / 20 °C 2: 92 percent / aq. Na2CO3 / acetone / 0 °C 3: 73 percent / aq.LiOH / tetrahydrofuran / 20 °C View Scheme
参考文献
Chemical Communications, , # 14 p. 1454 - 1455
反应条件
sodium hydroxide; sodium hydrogencarbonate in 1,4-dioxane; water T=0°C;
参考文献
Organic Letters, , vol. 8, # 2 p. 239 - 242
反应条件
1: 75.1 mg / aq. Na2CO3 / acetone / 5 h / 20 °C 2: 73 percent / aq. LiOH / tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 3, # 6 p. 1124 - 1128
反应条件
1: H2; 10-camphorsulfonic acid / Pd(OH)2/C / methanol / 0.5 h / 20 °C 2: 75.1 mg / aq. Na2CO3 / acetone / 5 h / 20 °C 3: 73 percent / aq. LiOH / tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 3, # 6 p. 1124 - 1128
