6-甲氧基吲哚-2-羧酸合成路线 （共 19 条）
反应条件
in quinoline 0.2 h; microwave;
参考文献
Jones, Graham B.; Chapman, Brant J.
Journal of Organic Chemistry, 1993 , vol. 58, # 20 p. 5558 - 5559
反应条件
1: 97.6 percent / Cu / quinoline / 2 h / Heating 2: 1.) POCl3, 3.) aq. NaOH 3: 1.) NaH / 1.) THF, 40 deg C, 90 min, 2.) THF, RT, 18 h View Scheme
参考文献
Allen; Hamaker; La Loggia; Cook
Synthetic Communications, 1992 , vol. 22, # 14 p. 2077 - 2102
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 14 h;
参考文献
Gore, Vivek; Gravel, Sylvie; Cossette, Chantal; Patel, Pranav; Chourey, Shishir; Ye, Qiuji; Rokach, Joshua; Powell, William S.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 2 p. 364 - 377
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C 2: manganese(IV) oxide / acetonitrile / 18 h / 20 °C View Scheme
参考文献
Gore, Vivek; Gravel, Sylvie; Cossette, Chantal; Patel, Pranav; Chourey, Shishir; Ye, Qiuji; Rokach, Joshua; Powell, William S.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 2 p. 364 - 377
反应条件
1: 87 percent / Cu; quinoline / Heating 2: 89 percent / phosphoryl chloride / 0 - 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 25 p. 6270 - 6282
参考文献
Pappalardo; Vitali
Gazzetta Chimica Italiana, 1958 , vol. 88, p. 574,589
反应条件
1.1: 87 percent / Cu; quinoline / Heating
2.1: 89 percent / phosphoryl chloride / 0 - 40 °C
3.1: NaOH / CH2Cl2 / 20 °C
3.2: 97 percent / CH2Cl2 / 20 °C
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: 87 percent / Cu; quinoline / Heating
2.1: 89 percent / phosphoryl chloride / 0 - 40 °C
3.1: NaOH / CH2Cl2 / 20 °C
3.2: 97 percent / CH2Cl2 / 20 °C
4.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
4.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
4.3: 91 percent / tetrahydrofuran; hexane / -78 - 0 °C
5.1: 80 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: 87 percent / Cu; quinoline / Heating
2.1: 89 percent / phosphoryl chloride / 0 - 40 °C
3.1: NaOH / CH2Cl2 / 20 °C
3.2: 97 percent / CH2Cl2 / 20 °C
4.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
4.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
4.3: 78 percent / tetrahydrofuran; hexane / -78 - 0 °C
5.1: 85 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
