2-(7-十二碳炔基氧基)四氢-2H-吡喃合成路线 （共 14 条）
反应条件
lithium amide in tetrahydrofuran; ammonia
参考文献
Binisti, Carine; Assogba, Leon; Touboul, Estera; Mounier, Carine; Huet, Jack; Ombetta, Jean-Edouard; Dong, Chang Zhi; Redeuilh, Catherine; Heymans, Francoise; Godfroid, Jean-Jacques
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 10 p. 809 - 828
反应条件
1: 60 percent / POCl3 2: 1.) lithium amide / hexamethylphosphoroamide, 1.) 1h, room temperature, 2.) 10 h, 55 deg C View Scheme
参考文献
Tomida, Ichiro; Mayesawa, Tsuneaki
Bioscience, Biotechnology, and Biochemistry, 1992 , vol. 56, # 12 p. 1962 - 1965
反应条件
1: 50 percent / 48percent hydrobromic acid / H2O; petroleum ether / 9 h / Heating 2: 60 percent / POCl3 3: 1.) lithium amide / hexamethylphosphoroamide, 1.) 1h, room temperature, 2.) 10 h, 55 deg C View Scheme
参考文献
Binisti, Carine; Assogba, Leon; Touboul, Estera; Mounier, Carine; Huet, Jack; Ombetta, Jean-Edouard; Dong, Chang Zhi; Redeuilh, Catherine; Heymans, Francoise; Godfroid, Jean-Jacques
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 10 p. 809 - 828
反应条件
1: 74 percent / POCl3 2: 1.) lithium amide / hexamethylphosphoroamide, 1.) 1h, room temperature, 2.) 10 h, 55 deg C View Scheme
参考文献
Tomida, Ichiro; Mayesawa, Tsuneaki
Bioscience, Biotechnology, and Biochemistry, 1992 , vol. 56, # 12 p. 1962 - 1965
反应条件
1: 74 percent / POCl3 2: 1.) lithium amide / hexamethylphosphoroamide, 1.) 1h, room temperature, 2.) 10 h, 55 deg C View Scheme
参考文献
Rossi, Renzo; Carpita, Adriano; Gaudenzi, Loretta; Quirici, Maria Grazia
Gazzetta Chimica Italiana, 1980 , vol. 110, # 4 p. 237 - 246
反应条件
1: 65 percent / NaOH / bis-(2-hydroxy-ethyl) ether 2: 1.) lithium amide / hexamethylphosphoroamide, 1.) 1h, room temperature, 2.) 10 h, 55 deg C View Scheme
参考文献
Kovalev, B. G.; Matveeva, E. D.; Stan, V. V.; Vovk, G. A.; Yudin, L. G.; Kost, A. N.
Journal of Organic Chemistry USSR (English Translation), 1980 , vol. 16, # 10 p. 1728 - 1733
Zhurnal Organicheskoi Khimii, 1980 , vol. 16, # 10 p. 2032 - 2038
反应条件
lithium amide hexamethylphosphoroamide, 1.) 1h, room temperature, 2.) 10 h, 55 deg C; Multistep reaction;
参考文献
Rossi, Renzo; Carpita, Adriano; Gaudenzi, Loretta; Quirici, Maria Grazia
Gazzetta Chimica Italiana, 1980 , vol. 110, # 4 p. 237 - 246
反应条件
lithium amide hexamethylphosphoroamide, 1.) 1h, room temperature, 2.) 10 h, 55 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Kovalev, B. G.; Matveeva, E. D.; Stan, V. V.; Vovk, G. A.; Yudin, L. G.; Kost, A. N.
Journal of Organic Chemistry USSR (English Translation), 1980 , vol. 16, # 10 p. 1728 - 1733
Zhurnal Organicheskoi Khimii, 1980 , vol. 16, # 10 p. 2032 - 2038
反应条件
lithium amide hexamethylphosphoroamide, 1.) 1h, room temperature, 2.) 10 h, 55 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Kovalev, B. G.; Matveeva, E. D.; Stan, V. V.; Vovk, G. A.; Yudin, L. G.; Kost, A. N.
Journal of Organic Chemistry USSR (English Translation), 1980 , vol. 16, # 10 p. 1728 - 1733
Zhurnal Organicheskoi Khimii, 1980 , vol. 16, # 10 p. 2032 - 2038
反应条件
1: H2; quinoline / 5 percent Pd/BaSO4 / hexane / 24 h / 40 °C / 1034.3 Torr
2: 92 percent / hydrogen chloride / methanol / 3 h / 4 °C
View Scheme
参考文献
Tomida, Ichiro; Mayesawa, Tsuneaki
Bioscience, Biotechnology, and Biochemistry, 1992 , vol. 56, # 12 p. 1962 - 1965
