1-氨基环戊烷-1-羧酸乙酯合成路线 （共 18 条）
反应条件
in toluene T=20°C; 24 h;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2004/72064 A1, 2004 ;
Location in patent: Page 14 ;
反应条件
1: diethyl ether 2: NaNO2, HCO2H View Scheme
参考文献
Johnston; McCaleb; Opliger; Montgomery
Journal of medicinal chemistry, 1966 , vol. 9, # 6 p. 892 - 911
反应条件
1: 96 percent / AcOH / xylene / 6.5 h / Heating 2: 1.) NaH / 1.) DMF, RT, 0.5 h, 2.) DMF, RT, 1 h 3: 68 percent / Bu3SnN3 / xylene / 88 h / Heating View Scheme
参考文献
Bernhart, Claude A.; Perreaut, Pierre M.; Ferrari, Bernard P.; Muneaux, Yvette A.; Assens, Jean-Louis A.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3371 - 3380
反应条件
lithium aluminium tetrahydride in diethyl ether Ambient temperature;
参考文献
Paulsen, Hans; Maass, Uwe
Chemische Berichte, 1981 , vol. 114, # 1 p. 346 - 358
反应条件
1: N-pentanoyl-N-[[2'-[N-(triphenylmethyl)tetrazol-5-yl]-1,1'-biphenyl-4-yl]methyl]amine With 2,6-dimethylpyridine; oxalyl dichloride in toluene T=0°C; 1 h; 2: ethyl 1-amino-1-cyclopentanecarboxylate in toluene T=0 - 20°C; 1 h;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2004/72064 A1, 2004 ;
Location in patent: Page 15 ;
反应条件
1: in toluene T=20°C; 2 h; 2: With acetic acid in toluene 5 h; Heating / reflux;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2004/72064 A1, 2004 ;
Location in patent: Page 13-14 ;
反应条件
1: 96 percent / AcOH / xylene / 6.5 h / Heating 2: 1.) NaH / 1.) DMF, RT, 0.5 h, 2.) DMF, RT, 1 h View Scheme
参考文献
Bernhart, Claude A.; Perreaut, Pierre M.; Ferrari, Bernard P.; Muneaux, Yvette A.; Assens, Jean-Louis A.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3371 - 3380
参考文献
Johnston; McCaleb; Opliger; Montgomery
Journal of medicinal chemistry, 1966 , vol. 9, # 6 p. 892 - 911
反应条件
acetic acid in xylene 6.5 h; Heating;
参考文献
Bernhart, Claude A.; Perreaut, Pierre M.; Ferrari, Bernard P.; Muneaux, Yvette A.; Assens, Jean-Louis A.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3371 - 3380
参考文献
Bertram, Juergen
Archiv der Pharmazie (Weinheim, Germany), 1981 , vol. 314, # 1 p. 44 - 51
