2-乙酰基-2'-羟基苯乙酮合成路线 （共 27 条）
反应条件
sodium acetate Kostanecki-Robinson reaction; 3 h; Inert atmosphereReflux;
参考文献
Stubbing, Louise A.; Li, Freda F.; Furkert, Daniel P.; Caprio, Vittorio E.; Brimble, Margaret A.
Tetrahedron, 2012 , vol. 68, # 34 p. 6948 - 6956
反应条件
1.1: 70 percent / conc. H2SO4 / 1 h / 4 °C 2.1: 60 percent / H2 / 5 percent Pd/CaCO3 / benzene / 18 h / 20 °C 3.1: isoamyl nitrite; conc. HCl / aq. ethanol / Heating 3.2: H2O View Scheme
参考文献
Ferrali, Marco; Donati, Donato; Bambagioni, Sabrina; Fontani, Marco; Giorgi, Gianluca; Pietrangelo, Antonello
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 11 p. 3041 - 3047
反应条件
1: Amberlist a-15 resin / isopropyl alcohol / 3 h / Reflux 2: methanol / 6 h / Reflux 3: bromine / chloroform / 0 - 20 °C 4: tetrakis(triphenylphosphine) palladium(0); triethylamine; triphenylphosphine / 1-methyl-pyrrolidin-2-one / 24 h / 100 °C / Inert atmosphere View Scheme
参考文献
Patonay, Tams; Vasas, Attila; Kiss-Szikszai, Attila; Silva, Artur M. S.; Cavaleiro, Jos A. S.
Australian Journal of Chemistry, 2010 , vol. 63, # 11 p. 1582 - 1593
反应条件
1: 1.) KOH / 1.) DMSO, water, ice-cooling, 4 h, 2.) room temp., 2 h 2: 79 percent / KOH / aq. ethanol / 0.5 h / Heating View Scheme
参考文献
Eiden; Rademacher
Archiv der Pharmazie, 1983 , vol. 316, # 1 p. 34 - 42
反应条件
in methanol 4 h; Heating;
参考文献
Ghosh, Chandra Kanta; Bhattacharya, Atanu
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 7 p. 668 - 670
反应条件
1: hydrogenchloride / water; methanol / 4 h / 20 °C 2: acetic anhydride / 14 h / |Reflux View Scheme
参考文献
Zheng, Yi; Zhao, Miao; Qiao, Qinglong; Liu, Huiying; Lang, Haijing; Xu, Zhaochao
Dyes and Pigments, 2013 , vol. 98, # 3 p. 367 - 371
反应条件
sodium hydroxide 2 h;
参考文献
Potnis; Samant
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 4 p. 817 - 820
反应条件
sodium hydride in tetrahydrofuran
T=20°C; Claisen condensation; Inert atmosphereReflux;
参考文献
Stubbing, Louise A.; Li, Freda F.; Furkert, Daniel P.; Caprio, Vittorio E.; Brimble, Margaret A.
Tetrahedron, 2012 , vol. 68, # 34 p. 6948 - 6956
反应条件
potassium tert-butylate in tetrahydrofuran
T=20°C; intramolecular Claisen condensation; 2 h;
参考文献
Santos, Clementina M. M.; Silva, Artur M. S.; Cavaleiro, Jose A. S.
Synlett, 2005 , # 20 art. no. D29105ST, p. 3095 - 3098
反应条件
1: 94 percent / pyridine / 15 h / 20 °C
2: 80 percent / t-BuOK / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Santos, Clementina M. M.; Silva, Artur M. S.; Cavaleiro, Jose A. S.
Synlett, 2005 , # 20 art. no. D29105ST, p. 3095 - 3098
