4-氯-3-硝基苯甲酸乙酯合成路线 （共 20 条）
反应条件
sulfuric acid in ethanol
参考文献
Japan Tobacco Inc.
Patent: US2003/50320 A1, 2003 ;
US 20030050320 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60°C; 3 h;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.
Patent: EP1726587 A1, 2006 ;
Location in patent: Page/Page column 47 ;
反应条件
sulfuric acid 4 h; Heating;
参考文献
Aguirre, Gabriela; Boiani, Mariana; Cerecetto, Hugo; Gerpe, Alejandra; Gonzalez, Mercedes; Sainz, Yolanda Fernandez; Denicola, Ana; De Ocariz, Carmen Ochoa; Nogal, Juan Jose; Montero, David; Escario, Jose Antonio
Archiv der Pharmazie, 2004 , vol. 337, # 5 p. 259 - 270
反应条件
ammonium cerium(IV) nitrate T=20°C; 144 h;
参考文献
Stefane, Bogdan; Kocevar, Marijan; Polanc, Slovenko
Synthetic Communications, 2002 , vol. 32, # 11 p. 1703 - 1707
参考文献
Justus Liebigs Annalen der Chemie, , vol. 222, p. 183
反应条件
tetrahydrofuran; potassium borohydride; lithium chloride
参考文献
McKay et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 4328,4330,4333
反应条件
potassium fluoride T=230°C;
参考文献
Farbw. Hoechst
Patent: US2891074 , 1954 ;
Full Text Show Details
Farbw. Hoechst
Patent: DE1018042 , 1953 ;
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide T=80°C; 6 h; 2: With hydrogen; palladium 10 on activated carbon in tetrahydrofuran T=20°C; 9 h; 3: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in DMF (N,N-dimethyl-formamide) T=20°C;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: US6713477 B1, 2004 ;
Location in patent: Page column 89-91 ;
US 6713477 B1
反应条件
2: H2 / Raney-Ni View Scheme
参考文献
Alkhader,M.A. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1979 , p. 1056 - 1062
反应条件
1: 98 percent / dimethylsulfoxide / 6 h / 70 °C 2: 99 percent / H2 / 20 percent Pd(OH)2/C / methanol / 24 h / 760 Torr View Scheme
参考文献
Skouta, Rachid; Dixon, Scott J.; Wang, Jianlin; Dunn, Denise E.; Orman, Marina; Shimada, Kenichi; Rosenberg, Paul A.; Lo, Donald C.; Weinberg, Joel M.; Linkermann, Andreas; Stockwell, Brent R.
Journal of the American Chemical Society, 2014 , vol. 136, # 12 p. 4551 - 4556
