2-羧基-3-硝基苯甲酸乙酯合成路线 （共 17 条）
反应条件
potassium carbonate in ethanol; sulfuric acid
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5128356 A1, 1992 ;
反应条件
1: HNO3+H2SO4 2: hydrogen chloride View Scheme
参考文献
Miller
Justus Liebigs Annalen der Chemie, 1881 , vol. 208, p. 230
参考文献
Faust
Justus Liebigs Annalen der Chemie, 1871 , vol. 160, p. 64
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Miller
Justus Liebigs Annalen der Chemie, 1881 , vol. 208, p. 230
参考文献
Miller
Justus Liebigs Annalen der Chemie, 1881 , vol. 208, p. 230
反应条件
1: SOCl2 / 1 h / Heating 2: aq. NaN3 / acetone / 1 h / below 25 deg C 3: aq. AcOH / 0.17 h / Heating 4: aq. KOH / Heating View Scheme
参考文献
Denny, William A.; Rewcastle, Gordon W.; Baguley, Bruce C.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 814 - 819
反应条件
ethanol; sodium acetate; methyl hydrazine sulfate
参考文献
Drew; Garwood
Journal of the Chemical Society, 1937 , p. 1841,1846
反应条件
1: SOCl2 / 1 h / Heating 2: aq. NaN3 / acetone / 1 h / below 25 deg C 3: aq. AcOH / 0.17 h / Heating 4: aq. KOH / Heating 5: H2, aq. NaOH / Pd/C View Scheme
参考文献
Denny, William A.; Rewcastle, Gordon W.; Baguley, Bruce C.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 814 - 819
反应条件
hydrazine hydrate entsteht in Form des Hydrazinsalzes;
参考文献
Curtius; Semper
Chemische Berichte, 1913 , vol. 46, p. 1170
反应条件
1: SOCl2 / 1 h / Heating 2: aq. NaN3 / acetone / 1 h / below 25 deg C 3: aq. AcOH / 0.17 h / Heating 4: aq. KOH / Heating 5: H2, aq. NaOH / Pd/C 6: cupric acetate, AcOH / H2O; methanol / Heating 7: 1.) 1,1'-carbonyldiimidazole / 1.) DMF, 40 deg C, 5 min, 2.) 10 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 2 p. 814 - 819
反应条件
1: SOCl2 / 1 h / Heating 2: aq. NaN3 / acetone / 1 h / below 25 deg C 3: aq. AcOH / 0.17 h / Heating 4: aq. KOH / Heating 5: H2, aq. NaOH / Pd/C 6: cupric acetate, AcOH / H2O; methanol / Heating View Scheme
参考文献
Denny, William A.; Rewcastle, Gordon W.; Baguley, Bruce C.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 814 - 819
